Doctoral School of Exact and Natural Sciences, University of Lodz, Banacha Street 12/16, 90-237 Lodz, Poland.
Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha St., 90-237 Lodz, Poland.
Int J Mol Sci. 2022 Mar 31;23(7):3847. doi: 10.3390/ijms23073847.
Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider the molecular basis of metastasis. The aim of this work is to provide a comprehensive review focusing on cancer metastasis and the mitogen-activated protein kinase (MAPK) pathway (ERK/JNK/P38 signaling) as a crucial modulator of this process.
癌症是全球主要的死亡原因之一。在许多情况下，由于癌细胞通过血液和淋巴引流转移到身体的远处部位，因此疾病的治疗受到限制。大多数抗癌治疗选择主要集中在抑制肿瘤细胞生长或诱导细胞死亡上，而不考虑转移的分子基础。这项工作的目的是提供一个全面的综述，重点关注癌症转移和丝裂原激活的蛋白激酶（MAPK）途径（ERK/JNK/P38 信号转导）作为这个过程的关键调节剂。
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