Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia.
Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia.
Curr Opin Allergy Clin Immunol. 2023 Aug 1;23(4):319-326. doi: 10.1097/ACI.0000000000000922. Epub 2023 Jun 23.
This review aims to summarize the most recent advances in asthma management, focusing on novel approaches to pediatric asthma.
In recent years, the therapeutic tools for pediatric asthma have expanded significantly for both the nonsevere and severe forms. The use of anti-inflammatory treatment, even for the mildest cases, and the withdrawal of symptomatic bronchodilation as monotherapy have been included in the most recent guidelines. Also, different biological therapies have revolutionized the therapeutical approach for severe uncontrolled asthma in children and adolescents.
With the expanding landscape of novel therapeutic approaches for pediatric asthma, further evidence is needed to help clinicians choose the best option for patients, particularly those with severe asthma. The identification of novel predictive biomarkers may also help pediatricians in selecting children and adolescents for innovative therapies.
本篇综述旨在总结哮喘管理的最新进展，重点关注儿科哮喘的新方法。
近年来，治疗儿科哮喘的手段有了显著扩展，既适用于非重症病例，也适用于重症病例。最新指南纳入了抗炎治疗（即使是轻度病例），并将症状性支气管扩张剂作为单一疗法撤下。此外，不同的生物疗法也彻底改变了儿童和青少年重度难治性哮喘的治疗方法。
随着儿科哮喘新型治疗方法的不断涌现，需要更多的证据来帮助临床医生为患者选择最佳方案，尤其是那些患有重度哮喘的患者。新型预测生物标志物的鉴定也可能有助于儿科医生为创新性疗法选择儿童和青少年患者。
