血清类胰蛋白酶与药物超敏反应：原因、机制和应对措施？一项系统性综述。
Serum tryptase and drug hypersensitivity: why, how and what? A systematic review.
机构信息
Synlab Provence, Marseille.
University of Montpellier, IDESP, INSERM UMR UA 11, Montpellier.
出版信息
Curr Opin Allergy Clin Immunol. 2023 Aug 1;23(4):294-299. doi: 10.1097/ACI.0000000000000916. Epub 2023 Jun 8.
PURPOSE OF REVIEW
Serum tryptase, a mast cell marker, provides clues for the mechanism, severity, and management of drug hypersensitivity induced by immunoglobulin E dependent or independent mast cell activation.
RECENT FINDINGS
The interpretation of serum tryptase levels has been challenged during the last 2 years by major advances in tryptase genetics and their rapid incorporation into clinical practice. On the contrary, new pathophysiological insight into nonmast cell-dependent immediate hypersensitivity has been gained.
SUMMARY
This review provides up-to-date information on the pathophysiology and recommended use and interpretation of tryptase in the context of drug hypersensitivity reactions as a function of their endotype.
目的综述
血清类胰蛋白酶是一种肥大细胞标志物，为免疫球蛋白 E 依赖性或非依赖性肥大细胞激活引起的药物过敏反应的机制、严重程度和管理提供线索。
最近的发现
在过去 2 年中，类胰蛋白酶遗传学的重大进展及其迅速纳入临床实践，对血清类胰蛋白酶水平的解读提出了挑战。相反，人们对非肥大细胞依赖性即刻过敏反应的新病理生理学有了更深入的了解。
总结
本文综述了药物过敏反应中类胰蛋白酶的病理生理学、推荐用途和解读，以及根据其表型的建议，提供了最新的信息。
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