Neurology Department, University Medical Center Ho Chi Minh City (University of Medicine and Pharmacy at Ho Chi Minh City), Ho Chi Minh City, Vietnam.
Division of Medical Toxicology, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
Clin Toxicol (Phila). 2023 Jun;61(6):476-478. doi: 10.1080/15563650.2023.2218026.
Organotin compounds are widely used in the plastic industry. We demonstrate the role of brain magnetic resonance imaging in a patient with leukoencephalopathy.
A 38-year-old man who worked with trimethyltin and dimethyltin in a polyvinyl chloride factory reported a two-week progression of impaired memory, loss of balance, apathy, tinnitus, scaly darkened skin, and psychomotor slowing that rendered him unable to continue his daily activities. Magnetic resonance imaging revealed diffuse bilateral white matter lesions. Tin concentrations in both blood (344 μ/L) and urine (3,050 μg/L) were elevated. Removal from exposure and treatment with succimer were associated with clinical, laboratory, and imaging improvements.
The high lipid content of myelin is a likely target for lipid-soluble alkyl tin compounds.
This patient demonstrates the clinical and magnetic resonance imaging findings of organotin toxicity. The contribution of chelation to the patient's recovery is uncertain and warrants further study.
有机锡化合物在塑料工业中被广泛应用。我们展示了一位白质脑病患者的脑部磁共振成像的作用。
一名 38 岁的男性在聚氯乙烯工厂中接触三甲基锡和二甲基锡，他报告说记忆受损、失去平衡、淡漠、耳鸣、皮肤鳞屑状变黑以及运动迟缓，这些症状持续了两周，使他无法继续日常活动。磁共振成像显示弥漫性双侧白质病变。血液（344 μ/L）和尿液（3050 μg/L）中的锡浓度升高。脱离接触并用二巯丁二酸治疗后，临床、实验室和影像学均有改善。
髓鞘的高脂质含量可能是脂溶性烷基锡化合物的靶标。
该患者表现出有机锡毒性的临床和磁共振成像表现。螯合治疗对患者恢复的贡献尚不确定，需要进一步研究。
