Ito H
Jpn J Pharmacol. 1986 May;41(1):131-4. doi: 10.1254/jjp.41.131.
W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a well-known inhibitor of the calmodulin-dependent processes, strongly enhanced phagocytosis and ingestion of polystyrene latex beads into the peritoneal macrophages of BALB/c mice after the i.p. injection, whereas W-5 [N-(6-aminohexyl)-naphthalene sulfonamide], a less effective calmodulin antagonist, was much weaker than W-7. Binding of the third component of complement (C3) cleavage to the C3 receptor on macrophages after the i.p. injection of W-7 was enhanced as shown by the fluorescent antibody technique. These data suggest that calmodulin plays an important role in the phagocytosis of macrophages through the complement system.
W - 7 [N - (6 - 氨基己基)-5 - 氯 - 1 - 萘磺酰胺]是一种著名的钙调蛋白依赖性过程抑制剂，腹腔注射后，它能显著增强BALB/c小鼠腹腔巨噬细胞对聚苯乙烯乳胶珠的吞噬和摄取，而W - 5 [N - (6 - 氨基己基)-萘磺酰胺]作为一种效果较差的钙调蛋白拮抗剂，其作用比W - 7弱得多。荧光抗体技术显示，腹腔注射W - 7后，补体第三成分（C3）裂解产物与巨噬细胞上C3受体的结合增强。这些数据表明，钙调蛋白通过补体系统在巨噬细胞的吞噬作用中发挥重要作用。
