长期的脑雾与 COVID-19 患者症状严重程度簇有关。

Long-lasting brain fog is related with severity clusters of symptoms in COVID-19 patients.

机构信息

Centro de Salud Familiar N° 1, Rancagua, Chile.

Hospital Regional Libertador Bernardo O'Higgins, Rancagua, Chile.

出版信息

Rev Med Chil. 2022 Nov;150(11):1484-1492. doi: 10.4067/S0034-98872022001101484.

DOI:10.4067/S0034-98872022001101484

PMID:37358174

Abstract

BACKGROUND

COVID-19 patients may experience Long-lasting symptoms from weeks to even months.

AIM

To evaluate long-term cognitive impairment based on the severity of symptoms of COVID-19 infection in a primary health system setting.

MATERIAL AND METHODS

From a database of 363 patients, 83 cases aged 47 ± 15 years, (58% females) were selected from June to August 2020. In patients who survived the virus, 24 infection-related symptoms were collected to create three severity clusters (mild, moderate, and severe). The follow-up time was at least seven months. Comparing the first two clusters with the severe cluster, the existence of brain fog and risk factors (obesity, hypertension, diabetes, chronic lung disease, and hypothyroidism) were analyzed.

RESULTS

Thirty-one patients (37%) had persistent symptoms lasting up to 240 days. Fifty-one patients (61%) experienced brain fog. Concentration was affected by symptom severity (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.26-10.46, p = 0.02). Short- or long-term memory loss was not affected. Moreover, symptom severity was related to brain fog (OR 3.16, 95% CI 1.05-9.51, p = 0.04). Patients with persistent symptoms had a concentration impairment associated with severity patterns (OR 24.3, 95% CI 1.73-340.11, p = 0.03).

CONCLUSIONS

Brain fog is associated with symptom severity in COVID-19 survivors and lasts for more than eight months.

摘要

背景

COVID-19 患者可能会出现持续数周甚至数月的长期症状。

目的

在基层医疗系统中，根据 COVID-19 感染症状的严重程度评估长期认知障碍。

材料和方法

从 363 名患者的数据库中，选取 2020 年 6 月至 8 月期间年龄为 47 ± 15 岁（女性占 58%）的 83 例病例。在病毒存活下来的患者中，收集了 24 种与感染相关的症状，以创建三个严重程度集群（轻度、中度和重度）。随访时间至少为 7 个月。将前两个集群与严重集群进行比较，分析脑雾和危险因素（肥胖、高血压、糖尿病、慢性肺病和甲状腺功能减退）的存在情况。

结果

31 名患者（37%）出现持续长达 240 天的持续症状。51 名患者（61%）出现脑雾。注意力受症状严重程度影响（优势比[OR]3.63，95%置信区间[CI]1.26-10.46，p=0.02）。短期或长期记忆丧失不受影响。此外，症状严重程度与脑雾相关（OR 3.16，95%CI 1.05-9.51，p=0.04）。有持续症状的患者注意力受损与严重程度模式相关（OR 24.3，95%CI 1.73-340.11，p=0.03）。