使用铁单宁纳米颗粒的 MRI 技术早期检测大鼠肝癌。
Early Detection of Hepatocarcinogenicity in Rats Using MRI with Ferric-Tannic Nanoparticles.
机构信息
Faculty of Associated Medical Sciences, Department of Radiologic Technology, Center of Excellence for Molecular Imaging (CEMI), Chiang Mai University, 50200 Chiang Mai, Thailand.
Faculty of Medicine, Department of Biochemistry, Chiang Mai University, 50200 Chiang Mai, Thailand.
出版信息
Anal Chem. 2023 Jul 11;95(27):10241-10248. doi: 10.1021/acs.analchem.3c00541. Epub 2023 Jun 26.
Herein, we present molecular nanoparticles of ferric-tannic complexes (so called ferric-tannic nanoparticles, FT NPs) used to enhance the MRI signal in the early stage of hepatocarcinoma. FT NPs were found to accumulate in the hepatic parenchyma without tumor nodules of Wistar rats in which hepatocarcinogenicity had been induced using diethylnitrosamine (DEN). The MRI enhancement and accumulation of FT NPs were clearly observed in the early phase of hepatocarcinogenicity, which was possibly modulated by various solute carrier family members present in the entire hepatic parenchyma of the DEN-induced rats. These findings suggest that MRI with FT NPs is promising for the assessment of the early stage of hepatocarcinoma.
在此，我们介绍了用于增强肝癌早期阶段 MRI 信号的铁单宁复合物的分子纳米颗粒（即铁单宁纳米颗粒，FT NPs）。研究发现，FT NPs 在未形成肿瘤结节的 Wistar 大鼠肝实质中蓄积，这些大鼠使用二乙基亚硝胺（DEN）诱导肝癌发生。在肝癌致癌作用的早期阶段，FT NPs 的 MRI 增强和蓄积现象清晰可见，这可能是由 DEN 诱导大鼠整个肝实质中存在的各种溶质载体家族成员所调节的。这些发现表明，FT NPs 的 MRI 有望用于评估肝癌的早期阶段。
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