Department of Dermatology, Medical University of Graz, Graz, Austria.
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Acta Derm Venereol. 2023 Jun 26;103:adv9403. doi: 10.2340/actadv.v103.9403.
Narrowband-ultraviolet B has shown increased efficacy over broadband-ultraviolet B in pruritic skin diseases, such as psoriasis and atopic dermatitis. In patients with chronic pruritus, e.g. in end-stage renal disease, broadband-ultraviolet B is recommended, but narrowband-ultraviolet B has also shown efficacy in reducing pruritus. This randomized, single blinded, non-inferiority study investigated the effects of narrowband-ultraviolet B compared with broadband-ultraviolet B. Patients with chronic pruritus were treated with either broadband- or narrowband-UVB 3 times a week for 6 weeks and clinical response was monitored. Pruritus, sleep disturbance, and the patients' subjective overall response to treatment were evaluated by the patients on a visual analogue scale (0-10). Skin excoriations were evaluated by investigators on a 4-point scale (0-3). Both phototherapeutic modalities showed significant antipruritic activity (itch reduction 48% and 66.4%, respectively) by broadband-ultraviolet B and narrowband-ultraviolet B. Narrowband-ultraviolet B proved to be not inferior to broadband-ultraviolet B in treating pruritus in patients with chronic pruritus, assuming a 20% non-inferiority margin.
窄谱中波紫外线在治疗瘙痒性皮肤病（如银屑病和特应性皮炎）方面比广谱中波紫外线更有效。对于慢性瘙痒症患者，如终末期肾病患者，推荐使用广谱中波紫外线，但窄谱中波紫外线也已显示出可减轻瘙痒的功效。这项随机、单盲、非劣效性研究调查了与广谱中波紫外线相比，窄谱中波紫外线的疗效。患有慢性瘙痒症的患者每周接受 3 次窄谱或广谱 UVB 治疗，共 6 周，并监测临床反应。瘙痒、睡眠障碍以及患者对治疗的主观整体反应由患者在视觉模拟量表（0-10）上进行评估。皮肤抓痕由研究者在 4 分制上进行评估（0-3）。广谱中波紫外线和窄谱中波紫外线均显示出显著的止痒作用（分别减少 48%和 66.4%的瘙痒）。在假设 20%非劣效性边界的情况下，窄谱中波紫外线在治疗慢性瘙痒症患者的瘙痒方面与广谱中波紫外线一样有效。
