Atci Tugba, Baykal Can
Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Photodermatol Photoimmunol Photomed. 2020 Jul;36(4):271-277. doi: 10.1111/phpp.12547. Epub 2020 Mar 21.
BACKGROUND/PURPOSE: We investigated the efficacy of narrow-band UVB in patch-stage MF and reviewed the literature to re-evaluate the role of this phototherapy method in early MF.
Early-stage MF patients treated with narrow-band UVB were included. Number of narrow-band UVB treatment sessions, treatment duration, cumulative UV dose, clinical response results, side effects, duration of the remission period and relapse rate were evaluated.
Complete response rate was 86.7% in sixty patients with MF. Mean number of treatment sessions was 62.9 ± 15.1, treatment duration was 32.1 ± 10.7 weeks, and mean cumulative UV dose was 62.1 ± 41.9 J/cm in patients with complete response. Mean duration of remission was 10.3 ± 11.0 months, and relapse rate was 70% in a mean follow-up of 21.9 ± 16.4 months. Mild regional erythema (6.7%) and pruritus (8.3%) were main side effects. There were no significant differences between stage IA and stage IB patients in terms of treatment parameters and duration of remission period.
Our study confirms that narrow-band UVB is effective for the management of the patch-stage MF without serious side effects. Extent of the skin lesions did not affect the efficacy of phototherapy. However, due to the short duration of remission, a further option such as an optimal maintenance therapy protocol should be considered.
背景/目的：我们研究了窄谱中波紫外线（NB-UVB）治疗斑块期蕈样肉芽肿（MF）的疗效，并回顾文献以重新评估这种光疗方法在早期MF中的作用。
纳入接受窄谱中波紫外线治疗的早期MF患者。评估窄谱中波紫外线治疗的次数、治疗持续时间、累积紫外线剂量、临床反应结果、副作用、缓解期持续时间和复发率。
60例MF患者的完全缓解率为86.7%。完全缓解患者的平均治疗次数为62.9±15.1次，治疗持续时间为32.1±10.7周，平均累积紫外线剂量为62.1±41.9 J/cm。平均缓解期为10.3±11.0个月，在平均21.9±16.4个月的随访中复发率为70%。主要副作用为轻度局部红斑（6.7%）和瘙痒（8.3%）。IA期和IB期患者在治疗参数和缓解期持续时间方面无显著差异。
我们的研究证实窄谱中波紫外线对斑块期MF的治疗有效且无严重副作用。皮肤病变范围不影响光疗效果。然而，由于缓解期较短，应考虑进一步的选择，如最佳维持治疗方案。
