Iakovlev S V, Glezer M G, Kholodov L E, Mikhaĭlov A A, Grigor'eva E A
Kardiologiia. 1986 May;26(5):33-6.
Elderly and old patients with subacute myocardial infarction showed elevated gastrointestinal digoxin absorption rates and a tendency to increased bioavailability of the drug, as compared to similar parameters in infarction-free patients of the same age, so that blood digoxin peaks were higher in the former. The demonstrated absorption changes may be related to limited physical activity of the myocardial infarction patients examined. Digoxin pharmacokinetic patterns are analysed with reference to baseline myocardial contractility.
与同龄无心肌梗死患者的类似参数相比，老年和高龄亚急性心肌梗死患者胃肠道地高辛吸收率升高，且药物生物利用度有增加趋势，因此前者的血地高辛峰值更高。所显示的吸收变化可能与所检查的心肌梗死患者身体活动受限有关。根据地高辛的基线心肌收缩力分析其药代动力学模式。
