Cusack B, Kelly J, O'Malley K, Noel J, Lavan J, Horgan J
Clin Pharmacol Ther. 1979 Jun;25(6):772-6. doi: 10.1002/cpt1979256772.
A study of single-dose digoxin kinetics was performed in 6 young and 7 elderly patients. The rate of absorption, determined by the time to peak concentration after an oral dose, was more rapid in the younger group. The extent of absorption, as measured by comparison of the area under the plasma concentration/time curve after oral and intravenous administration, was similar in both groups. Mean plasma half-life was longer and individual values were more variable in the elderly patients. The absolute apparent volume of distribution was reduced in the older patients and correlated inversely with age. When corrected for weight, however, the difference in the apparent volume of distribution did not approach significance. Both absolute and weight-corrected values for plasma clearance of digoxin were reduced in the elderly subjects.
对6名年轻患者和7名老年患者进行了单剂量地高辛动力学研究。通过口服给药后达到峰值浓度的时间确定的吸收速率，在年轻组中更快。通过比较口服和静脉给药后血浆浓度/时间曲线下的面积来衡量的吸收程度，在两组中相似。老年患者的平均血浆半衰期较长，个体值的变异性更大。老年患者的绝对表观分布容积减小，且与年龄呈负相关。然而，校正体重后，分布容积的差异无统计学意义。老年受试者地高辛的血浆清除率的绝对值和校正体重后的值均降低。
