Ziabreva E V, Bol'shakova T D, Gitel' E P, Lukovnikova L P, Podzolkov V I
Kardiologiia. 1986 May;26(5):64-7.
The relationship between water-salt balance and blood prolactin (Prl) level was examined in 22 male patients with essential hypertension, stages IB-IIA. Blood Prl and urinary potassium and sodium excretion were measured initially, using the parlodel (2.5 mg) test, and the acute and chronic furosemide test. Water-salt status was found to be different in patients with baseline hyperprolactinemia who made 2/3 of the sample. Following parlodel administration, Prl level declined in all patients, with daily electrolyte excretion also decreasing in originally-hyperprolactinemic patients. The rise in electrolyte excretion following lasix administration was accompanied with a fall in Prl in hyperprolactinemic patients. Following the chronic furosemide test, all patients showed a tendency to Prl rise, while the hyperprolactinemic patients also exhibited sodium retention. Therefore, blood Prl decrease leads to sodium retention in hyperprolactinemic hypertensive patients that may have an adverse pathogenetic significance.
对22例IB - IIA期原发性高血压男性患者的水盐平衡与血催乳素（Prl）水平之间的关系进行了研究。最初使用溴隐亭（2.5毫克）试验、急性和慢性速尿试验来测量血Prl以及尿钾和钠排泄量。发现占样本三分之二的基线高催乳素血症患者的水盐状态有所不同。服用溴隐亭后，所有患者的Prl水平均下降，原来高催乳素血症患者的每日电解质排泄量也减少。高催乳素血症患者服用速尿后电解质排泄量增加，同时Prl水平下降。慢性速尿试验后，所有患者均有Prl升高的趋势，而高催乳素血症患者也出现钠潴留。因此，血Prl降低会导致高催乳素血症高血压患者出现钠潴留，这可能具有不良的发病学意义。
