• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[新型冠状病毒肺炎相关肺功能减弱（CALW）：系统评价与荟萃分析]

[COVID-19-associated lung weakness (CALW): Systematic review and meta-analysis].

作者信息

Redruello-Guerrero Pablo, Ruiz-Del-Pino Marta, Jiménez-Gutiérrez Carmen, Jiménez-Gutiérrez Paula, Carrascos-Cáliz Ana, Romero-Linares Alejandro, Láinez Ramos-Bossini Antonio Jesús, Rivera-Izquierdo Mario, Cárdenas-Cruz Antonio

机构信息

Departamento de Medicina, Universidad de Granada, Granada, España.

Instituto Biosanitario de Granada (ibs GRANADA), Granada, España.

出版信息

Med Intensiva. 2023 Apr 26. doi: 10.1016/j.medin.2023.04.010.

DOI:10.1016/j.medin.2023.04.010
PMID:37359239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10130322/
Abstract

OBJECTIVES

To assess mortality and different clinical factors derived from the development of atraumatic pneumothorax (PNX) and/or pneumomediastinum (PNMD) in critically ill patients as a consequence of COVID-19-associated lung weakness (CALW).

DESIGN

Systematic review with meta-analysis.

SETTING

Intensive care unit (ICU).

PARTICIPANTS

Original research evaluating patients, with or without the need for protective invasive mechanical ventilation (IMV), with a diagnosis of COVID-19 who had developed atraumatic PNX or PNMD on admission or during their hospital stay.

INTERVENTIONS

Data of interest were obtained from each article and analysed and assessed by the Newcastle-Ottawa Scale. The risk of the variables of interest was assessed by data derived from studies including patients who developed atraumatic PNX or PNMD.

MAIN VARIABLES OF INTEREST

Mortality, mean ICU length of stay and mean PaO/FiO at diagnosis.

RESULTS

Data were collected from 12 longitudinal studies. Data from a total of 4,901 patients were included in the meta-analysis. A total of 1,629 patients had an episode of atraumatic PNX and 253 patients had an episode of atraumatic PNMD. Despite finding significantly strong associations, the high heterogeneity between studies means that interpretation of the results should be made with caution.

CONCLUSIONS

Mortality of COVID-19 patients was higher in those who developed atraumatic PNX and/or PNMD compared to those who did not. The mean PaO2/FiO2 index was lower in patients who developed atraumatic PNX and/or PNMD. We propose to group these cases under the term CAPD.

摘要

目的

评估因新型冠状病毒肺炎相关肺功能不全（CALW）导致的重症患者非创伤性气胸（PNX）和/或纵隔气肿（PNMD）的死亡率及不同临床因素。

设计

系统评价与荟萃分析。

地点

重症监护病房（ICU）。

参与者

评估确诊新型冠状病毒肺炎的患者（无论是否需要有创机械通气（IMV）），这些患者在入院时或住院期间发生了非创伤性PNX或PNMD。

干预措施

从每篇文章中获取感兴趣的数据，并通过纽卡斯尔-渥太华量表进行分析和评估。通过纳入发生非创伤性PNX或PNMD患者的研究数据来评估感兴趣变量的风险。

主要感兴趣变量

死亡率、ICU平均住院时间及诊断时的平均PaO/FiO。

结果

从12项纵向研究中收集数据。荟萃分析共纳入4901例患者的数据。共有1629例患者发生过非创伤性PNX，253例患者发生过非创伤性PNMD。尽管发现显著的强关联，但研究间的高度异质性意味着结果解释应谨慎。

结论

与未发生非创伤性PNX和/或PNMD的新型冠状病毒肺炎患者相比，发生者的死亡率更高。发生非创伤性PNX和/或PNMD的患者平均PaO2/FiO2指数更低。我们建议将这些病例归为CAPD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/a0428b206284/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/a38ba6c66c05/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/dc7867703895/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/a4eea451867b/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/cd04cae3e4a1/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/a0428b206284/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/a38ba6c66c05/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/dc7867703895/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/a4eea451867b/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/cd04cae3e4a1/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b4/10130322/a0428b206284/gr5_lrg.jpg

相似文献

1
[COVID-19-associated lung weakness (CALW): Systematic review and meta-analysis].[新型冠状病毒肺炎相关肺功能减弱（CALW）：系统评价与荟萃分析]
Med Intensiva. 2023 Apr 26. doi: 10.1016/j.medin.2023.04.010.
2
COVID-19-associated lung weakness (CALW): Systematic review and meta-analysis.COVID-19 相关肺功能减弱（CALW）：系统评价和荟萃分析。
Med Intensiva (Engl Ed). 2023 Oct;47(10):583-593. doi: 10.1016/j.medine.2023.06.001. Epub 2023 Jun 9.
3
Predictors of Pneumothorax/Pneumomediastinum in Mechanically Ventilated COVID-19 Patients.机械通气 COVID-19 患者气胸/纵隔气肿的预测因素。
J Cardiothorac Vasc Anesth. 2021 Dec;35(12):3642-3651. doi: 10.1053/j.jvca.2021.02.008. Epub 2021 Feb 6.
4
Incidence and risk factors for pneumomediastinum in COVID-19 patients in the intensive care unit.COVID-19 患者在重症监护病房发生气胸的发生率和危险因素。
Interact Cardiovasc Thorac Surg. 2022 Jan 18;34(2):236-244. doi: 10.1093/icvts/ivab258.
5
Risk factors of pneumothorax and pneumomediastinum in COVID-19: a matched case-control study.新型冠状病毒肺炎并发气胸和纵隔气肿的危险因素：一项病例对照研究。
BMC Infect Dis. 2023 Mar 7;23(1):137. doi: 10.1186/s12879-023-08104-3.
6
Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19: A structured summary of a study protocol for a randomised controlled trial.COVID-19 住院成人患者使用伊马替尼的安全性和疗效：一项随机对照试验研究方案的结构化总结。
Trials. 2020 Oct 28;21(1):897. doi: 10.1186/s13063-020-04819-9.
7
High-flow nasal cannula noninvasive ventilation in patients with COVID-19: a systematic review and meta-analysis.高流量鼻导管无创通气在 COVID-19 患者中的应用：系统评价和荟萃分析。
Ther Adv Respir Dis. 2022 Jan-Dec;16:17534666221087847. doi: 10.1177/17534666221087847.
8
Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis.针对无急性肺损伤或急性呼吸窘迫综合征的重症监护病房患者的机械通气策略：一项系统评价和网状荟萃分析。
Crit Care. 2016 Jul 22;20(1):226. doi: 10.1186/s13054-016-1396-0.
9
Limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation: evidence from critically ill COVID-19 patients.在高流量氧疗或无创通气期间急性呼吸窘迫综合征标准的局限性：来自危重症 COVID-19 患者的证据。
Crit Care. 2022 Mar 7;26(1):55. doi: 10.1186/s13054-022-03933-1.
10
A Case Series of Secondary Spontaneous Pneumomediastinum and Pneumothorax in Severe COVID-19 Pneumonia.重症新型冠状病毒肺炎继发自发性纵隔气肿和气胸病例系列
Cureus. 2022 Feb 15;14(2):e22247. doi: 10.7759/cureus.22247. eCollection 2022 Feb.

本文引用的文献

1
Incidence and risk factors of COVID-19 associated pneumothorax.COVID-19 相关气胸的发生率和危险因素。
PLoS One. 2022 Aug 5;17(8):e0271964. doi: 10.1371/journal.pone.0271964. eCollection 2022.
2
Comparison of radiographic pneumothorax and pneumomediastinum in COVID-19 vs. non-COVID-19 acute respiratory distress syndrome.COVID-19与非COVID-19急性呼吸窘迫综合征中影像学气胸和纵隔气肿的比较。
Intensive Care Med. 2022 Nov;48(11):1648-1651. doi: 10.1007/s00134-022-06816-9. Epub 2022 Aug 5.
3
A Case Series of Secondary Spontaneous Pneumomediastinum and Pneumothorax in Severe COVID-19 Pneumonia.
重症新型冠状病毒肺炎继发自发性纵隔气肿和气胸病例系列
Cureus. 2022 Feb 15;14(2):e22247. doi: 10.7759/cureus.22247. eCollection 2022 Feb.
4
Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes-a multicentre cohort study.COVID-19 后 12 个月的长期 COVID：因 COVID-19 住院和因其他原因住院的患者的持续症状——一项多中心队列研究。
BMC Med. 2022 Feb 23;20(1):92. doi: 10.1186/s12916-022-02292-6.
5
Pneumothorax and pneumomediastinum in patients with COVID-19: A retrospective study from tertiary care institute in India.COVID-19 患者的气胸和纵隔气肿：来自印度三级保健机构的回顾性研究。
Drug Discov Ther. 2021;15(6):310-316. doi: 10.5582/ddt.2021.01105.
6
Incidence and risk factors for pneumomediastinum in COVID-19 patients in the intensive care unit.COVID-19 患者在重症监护病房发生气胸的发生率和危险因素。
Interact Cardiovasc Thorac Surg. 2022 Jan 18;34(2):236-244. doi: 10.1093/icvts/ivab258.
7
Epidemiology, Risk Factors and Outcomes of Pneumomediastinum in Patients with Coronavirus Disease 2019: A Case-Control Study.新型冠状病毒病患者中纵隔气肿的流行病学、危险因素和转归：一项病例对照研究。
J Intensive Care Med. 2022 Jan;37(1):12-20. doi: 10.1177/08850666211040417. Epub 2021 Sep 13.
8
Outcomes of Barotrauma in Critically Ill COVID-19 Patients With Severe Pneumonia.危重症 COVID-19 合并严重肺炎患者气压伤的转归。
J Intensive Care Med. 2021 Oct;36(10):1176-1183. doi: 10.1177/08850666211023360. Epub 2021 Jun 21.
9
Serious complications in COVID-19 ARDS cases: pneumothorax, pneumomediastinum, subcutaneous emphysema and haemothorax.COVID-19 急性呼吸窘迫综合征病例中的严重并发症：气胸、纵隔气肿、皮下气肿和血胸。
Epidemiol Infect. 2021 Jun 8;149:e137. doi: 10.1017/S0950268821001291.
10
Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study.COVID-19 住院后后遗症、持续症状和结局：ANCOHVID 多中心 6 个月随访研究。
BMC Med. 2021 May 20;19(1):129. doi: 10.1186/s12916-021-02003-7.