Hu Daniel, Yuen Cary
Providence St. Peter Hospital, Olympia, WA, USA.
Consultative Internal Medicine, Kaiser Permanente, Olympia, WA, USA.
Hosp Pharm. 2023 Aug;58(4):350-352. doi: 10.1177/00185787231151862. Epub 2023 Mar 17.
Silver-containing products have been used for medicinal purposes since antiquity. Throughout the ages and indeed up until the present time, silver has been employed with the hopes of treating a myriad of diseases including the common cold, skin problems, infections, and even cancer. However, silver has no known biological role in human physiology, and taking silver may lead to adverse reactions. The better-known adverse reactions of silver include argyria, or a gray-blue cutaneous discoloration, which is a known effect of silver accumulation. Additionally renal or hepatic injury may also be experienced. Reports of neurological adverse reactions are rare, however, and the extant medical literature contains very few descriptions of such cases. We report herein a case of a 70 year old man who presented with seizures as the sole manifestation of silver toxicity after self-medicating with colloidal silver.
含银产品自古以来就被用于医疗目的。从古至今,人们一直希望用银来治疗包括普通感冒、皮肤问题、感染甚至癌症在内的多种疾病。然而,银在人体生理学中并无已知的生物学作用,服用银可能会导致不良反应。银较常见的不良反应包括银质沉着病,即皮肤出现灰蓝色变色,这是银积累的已知效应。此外,还可能出现肾或肝损伤。关于神经不良反应的报告很少,现存的医学文献中对此类病例的描述也非常少。我们在此报告一例70岁男性病例,该患者在自行服用胶体银后,癫痫发作是银中毒的唯一表现。