Liu Jiaxin, Cao Chuanshang, Jin Yiran, Wang Yan, Ma Xiaona, Li Jiahui, Guo Songlin, Yang Jiancheng, Niu Jianguo, Liang Xueyun
Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, 750001 Yinchuan, China.
Ningxia Key Laboratory of Cerebrocranial Diseases, Ningxia Medical University, 750004 Yinchuan, China.
iScience. 2023 Jun 7;26(7):107022. doi: 10.1016/j.isci.2023.107022. eCollection 2023 Jul 21.
Intracerebral hemorrhage usually manifests as strong neuroinflammation and neurological deficits. There is an urgent need to explore effective methods for the treatment of intracerebral hemorrhage. The therapeutic effect and the possible mechanism of induced neural stem cell transplantation in an intracerebral hemorrhage rat model are still unclear. Our results showed that transplantation of induced neural stem cells could improve neurological deficits by inhibiting inflammation in an intracerebral hemorrhage rat model. Additionally, induced neural stem cell treatment could effectively suppress microglial pyroptosis, which might occur through inhibiting the NF-κB signaling pathway. Induced neural stem cells could also regulate the polarization of microglia and promote the transition of microglia from pro-inflammatory phenotypes to anti-inflammatory phenotypes to exert their anti-inflammatory effects. Overall, induced neural stem cells may be a promising tool for the treatment of intracerebral hemorrhage and other neuroinflammatory diseases.
脑出血通常表现为强烈的神经炎症和神经功能缺损。迫切需要探索治疗脑出血的有效方法。在脑出血大鼠模型中，诱导神经干细胞移植的治疗效果及可能机制仍不清楚。我们的结果表明，在脑出血大鼠模型中，诱导神经干细胞移植可通过抑制炎症来改善神经功能缺损。此外，诱导神经干细胞治疗可有效抑制小胶质细胞焦亡，这可能是通过抑制NF-κB信号通路实现的。诱导神经干细胞还可调节小胶质细胞的极化，促进小胶质细胞从促炎表型向抗炎表型转变，从而发挥其抗炎作用。总体而言，诱导神经干细胞可能是治疗脑出血及其他神经炎症性疾病的一种有前景的工具。
