依诺肝素治疗继发的胆汁淤积型肝毒性。
Hepatotoxicity with cholestatic pattern secondary to enoxaparin treatment.
作者信息
Velasco de Cos Guillermo, Sánchez-Molina Acosta Isabel, Iturralde Ros Marta, Maiztegi Azpitarte Ainhoa, Moyano Martinez Ana
机构信息
Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain.
Hospital Comarcal de Laredo, Laredo, Cantabria, Spain.
出版信息
Adv Lab Med. 2021 Nov 3;2(4):575-582. doi: 10.1515/almed-2021-0048. eCollection 2021 Nov.
OBJECTIVES
Treatment with low-molecular-weight heparins is very common in clinical practice. Exceptionally, some patients develop hepatitis within a few days of starting treatment, and rapid discontinuation of the drug is decisive to avoid chronification.
CASE PRESENTATION
These episodes usually present themselves only with elevated transaminases. We describe the case of a patient who presented a cholestatic pattern, which is very uncommon with this type of drug.
CONCLUSIONS
Hepatitis secondary to heparin therapy is an underdiagnosed entity. The laboratory plays a fundamental role in its diagnosis, given that it initially presents itself without a clear clinical profile.
目的
低分子量肝素治疗在临床实践中非常常见。例外的是，一些患者在开始治疗后的几天内会出现肝炎，迅速停药对于避免病情慢性化至关重要。
病例介绍
这些发作通常仅表现为转氨酶升高。我们描述了一名出现胆汁淤积型的患者病例，这种情况在这类药物中非常罕见。
结论
肝素治疗继发的肝炎是一种诊断不足的疾病。鉴于其最初表现缺乏明确的临床特征，实验室检查在其诊断中起着至关重要的作用。
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