Mahmoudi Morteza, Landry Markita P, Moore Anna, Coreas Roxana
Department of Radiology and Precision Health Program, Michigan State University, East Lansing, MI USA.
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA USA.
Nat Rev Mater. 2023 Mar 24:1-17. doi: 10.1038/s41578-023-00552-2.
The protein corona spontaneously develops and evolves on the surface of nanoscale materials when they are exposed to biological environments, altering their physiochemical properties and affecting their subsequent interactions with biosystems. In this Review, we provide an overview of the current state of protein corona research in nanomedicine. We next discuss remaining challenges in the research methodology and characterization of the protein corona that slow the development of nanoparticle therapeutics and diagnostics, and we address how artificial intelligence can advance protein corona research as a complement to experimental research efforts. We then review emerging opportunities provided by the protein corona to address major issues in healthcare and environmental sciences. This Review details how mechanistic insights into nanoparticle protein corona formation can broadly address unmet clinical and environmental needs, as well as enhance the safety and efficacy of nanobiotechnology products.
当纳米级材料暴露于生物环境时，蛋白质冠层会在其表面自发形成并演化，改变其物理化学性质，并影响其随后与生物系统的相互作用。在本综述中，我们概述了纳米医学中蛋白质冠层研究的现状。接下来，我们讨论蛋白质冠层研究方法和表征方面仍然存在的挑战，这些挑战减缓了纳米颗粒治疗和诊断的发展，并且我们阐述了人工智能如何作为实验研究工作的补充推进蛋白质冠层研究。然后，我们综述了蛋白质冠层为解决医疗保健和环境科学中的重大问题提供的新机遇。本综述详细介绍了对纳米颗粒蛋白质冠层形成的机理认识如何广泛地满足未满足的临床和环境需求，以及提高纳米生物技术产品的安全性和有效性。
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