来源于地上部分的咖啡酰奎宁酸类似物对脂肪生成的影响。
Effects of caffeoylquinic acid analogs derived from aerial parts of on adipogenesis.
作者信息
Han Su-Young, Kim Jisu, Kim Bo Kyeong, Whang Wan Kyunn, Min Hyeyoung
机构信息
College of Pharmacy, Chung-Ang University, 84 Heukseokro, Dongjakgu, Seoul, 06974 Korea.
出版信息
Food Sci Biotechnol. 2023 Feb 6;32(9):1215-1223. doi: 10.1007/s10068-023-01262-9. eCollection 2023 Aug.
(AI) is a perennial herb found in Korea. Its ground parts are dried and used in food and traditional medicine for treating hepatitis, inflammation, cholelithiasis, and jaundice. In this study, the anti-obesity effects of single compounds isolated from AI extracts on adipose tissue were investigated. Results demonstrated that caffeoylquinic acid analogs strongly inhibited adipocyte differentiation from 3T3-L1 preadipocytes and reduced neutral lipids in differentiated adipocytes. Accordingly, lipid accumulation in adipocytes decreased, and lipid droplets became granulated. Caffeoylquinic acid analogs suppressed the expression of adipocyte differentiation marker genes, namely, Cebpa, Lep, and Fabp4, but it induced the expression of Ucp1, Ppargc1a, and Fgf21, which are browning biomarkers. Therefore, caffeoylquinic acid analogs from AI inhibited preadipocyte differentiation and induced adipose tissue browning, suggesting that these compounds could be promising therapeutic agents for obesity.
（某植物名称，暂音译为“AI”）是一种在韩国发现的多年生草本植物。其地上部分经干燥后用于食品和传统医学，可治疗肝炎、炎症、胆石症和黄疸。在本研究中，对从AI提取物中分离出的单一化合物对脂肪组织的抗肥胖作用进行了研究。结果表明，咖啡酰奎尼酸类似物强烈抑制3T3-L1前脂肪细胞的脂肪细胞分化，并减少分化脂肪细胞中的中性脂质。因此，脂肪细胞中的脂质积累减少，脂滴变得颗粒化。咖啡酰奎尼酸类似物抑制脂肪细胞分化标记基因Cebpa、Lep和Fabp4的表达，但诱导褐色化生物标志物Ucp1、Ppargc1a和Fgf21的表达。因此，来自AI的咖啡酰奎尼酸类似物抑制前脂肪细胞分化并诱导脂肪组织褐色化，表明这些化合物可能是有前景的肥胖治疗药物。
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