Lin Wei-Kuan, Ni Linyu, Wang Xueding, Guo Jay L, Xu Guan
Department of Electrical Engineering and Computer Sciences, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI, USA.
Department of Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI, USA.
Photoacoustics. 2023 Jun 2;31:100519. doi: 10.1016/j.pacs.2023.100519. eCollection 2023 Jun.
In our previous study, we demonstrated the feasibility of using an all-optical interstitial photoacoustic (PA) needle sensing probe for quantitative study of tissue architectures with PA spectral analysis (PASA). In this work, we integrated the optical components into an 18 G steel needle sheath for clinical translation. The dimensions of the needle probe are identical to those of a core biopsy probe and are fully compatible with standard procedures such as prostate biopsy. To our knowledge, this is the first interstitial PA probe that can acquire signals with sufficient temporal length for statistics-based PASA. We treated the inner surface of the steel needle sheath and successfully suppressed the vibrational PA signals generated at the surface. Purposed at boosting the measurement sensitivity and extending sensing volume, we upgraded the Fabry-Pérot hydrophone with a plano-concave structure. The performance of the translational needle PA sensing probe was examined with phantoms containing microspheres. The trend of the linear spectral slopes shows negatively correlated to the microsphere dimensions while the midband-fits are positively correlated to microsphere diameters and concentrations. The PASA quantifications show the ability to differentiate microspheres with varied dimensions.
在我们之前的研究中,我们展示了使用全光学间质光声(PA)针传感探头通过光声光谱分析(PASA)对组织结构进行定量研究的可行性。在这项工作中,我们将光学组件集成到一个18G钢针护套中,以实现临床转化。针探头的尺寸与芯针活检探头相同,并且与前列腺活检等标准程序完全兼容。据我们所知,这是第一个能够获取具有足够时间长度信号以进行基于统计的PASA的间质PA探头。我们对钢针护套的内表面进行了处理,并成功抑制了在表面产生的振动PA信号。为了提高测量灵敏度并扩大传感体积,我们对具有平凹结构的法布里-珀罗水听器进行了升级。使用含有微球的体模对平移针PA传感探头的性能进行了检测。线性光谱斜率的趋势与微球尺寸呈负相关,而中频拟合与微球直径和浓度呈正相关。PASA定量显示了区分不同尺寸微球的能力。