Taloyan Marina, Steiner Kristin Hjörleifdottir, Östenson Claes-Göran, Salminen Helena
Division of Family Medicine and Primary Care, Department of Neurobiology, Department of Neurobiology, Care sciences and Society, Karolinska Institutet, Alfred Nobels allé 23, Huddinge, S-141 83 Sweden.
Academic Primary Health Care Centre, Region Stockholm, Box 45436, Stockholm, 104 31 Sweden.
J Diabetes Metab Disord. 2023 May 22;22(2):1-7. doi: 10.1007/s40200-023-01226-0.
To determine fasting plasma glucose and serum 25-hydroxyvitamin D (s-25(OH)D) levels and associations between abnormal fasting plasma glucose levels and inadequate s-25(OH)D levels in individuals of Middle Eastern and Swedish descent.
Observational study with individuals without a diabetes diagnosis, 54.5% of Swedish descent and 45.5% of Middle Eastern descent. In total, 830 participants from two primary healthcare centres in Flemingsberg and Jakobsberg, which are southern and northern suburbs, respectively, of Stockholm, Sweden were included in the study.
Prevalence of inadequate s-25(OH)D levels (at or below 50 nmol/L) was 67.2% among those of Middle Eastern descent and 20.5% among those of Swedish descent ( < 0.001). S-25(OH)D levels correlated weakly positively with fasting plasma glucose levels (ρ = 0.20, = 0.002) in individuals of Middle Eastern descent. Being of Middle Eastern descent (OR 6.7, 95% CI 4.3-10.4) and having abnormal fasting plasma glucose (OR 1.8, 95% CI 1.2-2.9) were independent predictors of having inadequate s-25(OH)D levels.
Healthcare in Sweden should consider testing fasting plasma glucose and s-25(OH)D levels, particularly in individuals of Middle Eastern descent. The unclear relationship between vitamin D and glucose levels warrants investigation.
The online version contains supplementary material available at 10.1007/s40200-023-01226-0.
测定中东和瑞典裔个体的空腹血糖和血清25-羟基维生素D（s-25(OH)D）水平，以及空腹血糖异常水平与s-25(OH)D水平不足之间的关联。
对未诊断为糖尿病的个体进行观察性研究，其中54.5%为瑞典裔，45.5%为中东裔。该研究共纳入了来自瑞典斯德哥尔摩南部和北部分别为弗莱明斯贝里和雅各布斯贝里的两个初级医疗保健中心的830名参与者。
中东裔个体中s-25(OH)D水平不足（低于或等于50 nmol/L）的患病率为67.2%，瑞典裔个体中为20.5%（P<0.001）。在中东裔个体中，s-25(OH)D水平与空腹血糖水平呈弱正相关（ρ = 0.20，P = 0.002）。中东裔（比值比6.7，95%置信区间4.3 - 10.4）和空腹血糖异常（比值比1.8，95%置信区间1.2 - 2.9）是s-25(OH)D水平不足的独立预测因素。
瑞典的医疗保健应考虑检测空腹血糖和s-25(OH)D水平，特别是在中东裔个体中。维生素D与血糖水平之间不明确的关系值得研究。
在线版本包含可在10.1007/s40200-023-01226-0获取的补充材料。
