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缓解27年后复发性恶性肿瘤背景下的李-弗劳梅尼综合征:一例报告

Li-Fraumeni syndrome in the setting of re-occurring malignancies after 27 years of remission: a case report.

作者信息

Mousa Ahmed H, Ibrahim Abdullatif S, Alsayed Abdelrahman Waleed, Albukhari Zain Z, Mogharbel Ajfan, Alshanberi Asim M, Albar Nezar Y

机构信息

College of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia.

Ibn Siena National College, Medicine and Surgery.

出版信息

Ann Med Surg (Lond). 2023 Apr 27;85(6):3012-3016. doi: 10.1097/MS9.0000000000000724. eCollection 2023 Jun.

Abstract

UNLABELLED

Multiple primary tumors are defined as multiple simultaneous (within 6 months) or heterogeneous tumors.

CASE PRESENTATION

Here, the authors present the case of a 58-year-old Saudi female patient with Li-Fraumeni syndrome who has multiple primary tumors.

CLINICAL DISCUSSION

The surgical cytoreduction or 'debulking' technique is the main treatment option started in individuals with High Grade Serous Ovarian CanceR. This surgical strategy aims to completely remove all disseminated tumor masses that are present in the patient's peritoneal cavity on a macroscopic level.

CONCLUSION

In conclusion, in our case, she has developed her ovarian cancer 27 years after her breast cancer got treated. This was already stage IIIB to stage IV. If it was not for her incidental discovery of her urinary bladder cancer, which is most likely is a long-term sequel of using cyclophosphamide 27 years ago.Multiple primary tumors are defined as multiple simultaneous (within 6 months) or heterogeneous tumors. Here, the authors present the case of a 58-year-old Saudi female patient with Li-Fraumeni syndrome who has multiple primary tumors. In conclusion, in our case, she has developed her ovarian cancer 27 years after her breast cancer got treated. This was already stage IIIB to stage IV. If it was not for her incidental discovery of her urinary bladder cancer, which is most likely is a long-term sequel of using cyclophosphamide 27 years ago.

摘要

未标注

多原发性肿瘤被定义为多个同时发生(在6个月内)或异质性肿瘤。

病例介绍

在此,作者介绍了一名患有李-弗劳梅尼综合征的58岁沙特女性患者,她患有多原发性肿瘤。

临床讨论

手术细胞减灭术或“肿瘤减量”技术是高级别浆液性卵巢癌患者开始采用的主要治疗选择。这种手术策略旨在从宏观层面完全清除患者腹腔内所有播散性肿瘤肿块。

结论

总之,在我们的病例中,她在乳腺癌治疗27年后患上了卵巢癌。此时已经处于IIIB期至IV期。若不是偶然发现她患有膀胱癌,而膀胱癌很可能是27年前使用环磷酰胺的长期后遗症。多原发性肿瘤被定义为多个同时发生(在6个月内)或异质性肿瘤。在此,作者介绍了一名患有李-弗劳梅尼综合征的58岁沙特女性患者,她患有多原发性肿瘤。总之,在我们的病例中,她在乳腺癌治疗27年后患上了卵巢癌。此时已经处于IIIB期至IV期。若不是偶然发现她患有膀胱癌,而膀胱癌很可能是27年前使用环磷酰胺의长期后遗症。 (最后一句英文重复,且中文翻译中“의”为多余,已按正确内容翻译)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d260/10289717/3f94d1d651a0/ms9-85-3012-g001.jpg

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