Bernstein J E, Medenica M, Soltani K, Griem S F
Arch Dermatol. 1979 Mar;115(3):324-5.
Bullous eruption of diabetes is a cutaneous sign of diabetes mellitus. Patients with this disorder manifest a sudden onset of intraepidermal or subepidermal bullae, which are primarily confined to the extremities and heal within several weeks without scarring. Our patient had severe diabetes and experienced two episodes of bullae associated with intense, ultraviolet light exposure. Negative immunofluorescence, early disappearance of anchoring filaments and half-desmosomes between cell membrane and basal lamina, and the absence of urinary uroporphyrins separate this entity from certain similar-appearing conditions. Cation imbalance, precipitated by renal failure, could be a possible causal factor.
糖尿病大疱性皮疹是糖尿病的一种皮肤表现。患有这种疾病的患者会突然出现表皮内或表皮下大疱，主要局限于四肢，数周内愈合且不留疤痕。我们的患者患有严重糖尿病，经历了两次与强烈紫外线照射相关的大疱发作。阴性免疫荧光、细胞膜与基膜之间锚定细丝和半桥粒的早期消失以及尿中尿卟啉的缺乏将这种疾病与某些外观相似的病症区分开来。由肾衰竭引发的阳离子失衡可能是一个潜在的致病因素。
