Gebhard R L, Sievert C E, Prigge W F
Lipids. 1986 Jun;21(6):420-1. doi: 10.1007/BF02534940.
Activity of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34) measured in isolated segments of canine intestinal mucosa showed a distinct diurnal rhythm. Total activity changed over a twofold range with a peak occurring during midday, shortly after feeding. Since the isolated segments had no contact with luminal contents, the rhythm was not directly related to food components or bile salts. Humoral or neural influences must mediate the rhythm. The diurnal rhythm persisted for at least 3-5 mo, but was lost by 10 mo following formation of the isolated segment, possibly because of mucosal involution.
在犬肠道黏膜分离段中测得的3-羟基-3-甲基戊二酰辅酶A还原酶（EC 1.1.1.34）的活性呈现出明显的昼夜节律。总活性在两倍范围内变化，峰值出现在中午喂食后不久。由于分离段与管腔内容物无接触，该节律与食物成分或胆汁盐无直接关系。体液或神经影响必定介导了这种节律。昼夜节律持续至少3 - 5个月，但在分离段形成后10个月时消失，可能是由于黏膜退化。
