儿童疟疾中的肝功能障碍
Hepatic dysfunction in childhood malaria.
作者信息
Patwari A, Aneja S, Berry A M, Ghosh S
出版信息
Arch Dis Child. 1979 Feb;54(2):139-41. doi: 10.1136/adc.54.2.139.
Hepatic function of 80 children aged under 3 years with Plasmodium vivax malaria were studied during the acute attack and 6 weeks after antimalarial treatment. Raised levels of serum aspartate transaminase (serum AST; SGOT), serum alanine transaminase (serum ALT; SGPT), and alkaline phosphatase were observed in 68%, 39% and 46% of cases respectively. AST levels were higher than ALT ones and the mean level of both enzymes was much higher in patients with hepatomegaly. The hepatic dysfunction which these observations reflect is transient, as these enzymes were found to be at their normal levels 6 weeks after treatment. A transient derangement of liver function is thus a common feature of childhood malaria, and hepatic dysfunction takes place to a significant degree even in P. vivax malaria.
对80名3岁以下间日疟原虫疟疾患儿在急性发作期及抗疟治疗6周后进行了肝功能研究。分别有68%、39%和46%的病例血清天冬氨酸转氨酶（血清AST；SGOT）、血清丙氨酸转氨酶（血清ALT；SGPT）和碱性磷酸酶水平升高。AST水平高于ALT水平，肝肿大患者中这两种酶的平均水平要高得多。这些观察结果所反映的肝功能障碍是短暂的，因为治疗6周后发现这些酶的水平恢复正常。因此，肝功能的短暂紊乱是儿童疟疾的一个常见特征，即使是间日疟原虫疟疾，肝功能障碍也会在很大程度上发生。
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