斯派克和波放电检测在斯特拉斯堡的遗传失神发作大鼠和遗传全面性癫痫患者。

Spike and wave discharges detection in genetic absence epilepsy rat from Strasbourg and patients with genetic generalized epilepsy.

机构信息

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia; Department of Neurology, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia.

Department of Neurology, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia; Department of Neurology, The Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia.

出版信息

Epilepsy Res. 2023 Aug;194:107181. doi: 10.1016/j.eplepsyres.2023.107181. Epub 2023 Jun 15.

DOI:10.1016/j.eplepsyres.2023.107181

PMID:37364342

Abstract

OBJECTIVE

Generalised spike and wave discharges (SWDs) are pathognomonic EEG signatures for diagnosing absence seizures in patients with Genetic Generalized Epilepsy (GGE). The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is one of the best-validated animal models of GGE with absence seizures.

METHODS

We developed an SWDs detector for both GAERS rodents and GGE patients with absence seizures using a neural network method. We included 192 24-hour EEG sessions recorded from 18 GAERS rats, and 24-hour scalp-EEG data collected from 11 GGE patients.

RESULTS

The SWDs detection performance on GAERS showed a sensitivity of 98.01% and a false positive (FP) rate of 0.96/hour. The performance on GGE patients showed 100% sensitivity in five patients, while the remaining patients obtained over 98.9% sensitivity. Moderate FP rates were seen in our patients with 2.21/hour average FP. The detector trained within our patient cohort was validated in an independent dataset, TUH EEG Seizure Corpus (TUSZ), that showed 100% sensitivity in 11 of 12 patients and 0.56/hour averaged FP.

CONCLUSIONS

We developed a robust SWDs detector that showed high sensitivity and specificity for both GAERS rats and GGE patients.

SIGNIFICANCE

This detector can assist researchers and neurologists with the time-efficient and accurate quantification of SWDs.

摘要

目的

泛化棘波和尖波放电（SWD）是诊断遗传全面性癫痫（GGE）患者失神发作的特征性脑电图标志。斯特拉斯堡遗传性失神癫痫大鼠（GAERS）是具有失神发作的 GGE 的最佳验证动物模型之一。

方法

我们使用神经网络方法为具有失神发作的 GAERS 啮齿动物和 GGE 患者开发了一种 SWD 检测器。我们纳入了 18 只 GAERS 大鼠的 192 小时 EEG 记录和 11 名 GGE 患者的 24 小时头皮 EEG 数据。

结果

GAERS 上的 SWD 检测性能显示出 98.01%的敏感性和 0.96/小时的假阳性（FP）率。在五名患者中，对 GGE 患者的性能显示出 100%的敏感性，而其余患者的敏感性超过 98.9%。我们的患者中 FP 率适中，平均为 2.21/小时。在我们的患者队列中训练的检测器在独立数据集 TUH EEG 发作语料库（TUSZ）中得到验证，在 12 名患者中的 11 名中显示出 100%的敏感性和 0.56/小时的平均 FP。