Flores-Mancilla Leopoldo Eduardo, Hernández-González Marisela, Guevara-Pérez Miguel Ángel, Bonilla-Jaime Herlinda, Gaytán-Pacheco Noemí, Reyes-Estrada Claudia Araceli, Pacheco-Moisés Fermín Paul
Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Ejido la Escondida, Zacatecas 98160, CP, Mexico.
Instituto de Neurociencias, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Francisco de Quevedo No. 180, Col. Arcos Vallarta, Guadalajara 44130, CP, Mexico.
Brain Sci. 2025 Apr 14;15(4):395. doi: 10.3390/brainsci15040395.
Febrile seizures (FS) are neuronal disturbances frequently associated with abnormal electroencephalographic activity (EEG) as spike-wave discharges (SWDs). Fish oil (FO) has high amounts of omega-3 fatty acids (θ-3), and its effects on FS alterations are poorly understood. The aim of this work was to evaluate the effect of long-term FO supplementation on the EEG of the amygdala of adult male rats with early-life FS. Progenitor female Wistar rats, from puberty to gestation and delivery, were fed daily with a commercial diet supplemented with either fish oil (FO), palm oil (PO), or deionized water (CTRL). After parturition, male pups were exposed for 30 min to hyperthermia (HP) and then returned to their dams. After weaning, pups were fed a commercial diet and the respective treatments up to 155 days of age when electrodes were implanted in the amygdala. During early life HP, the PO and CTRL groups reached maximal core temperature (CT) in comparison with the FO group. Furthermore, the FO group only has fewer myoclonus and long latency to adopt an uncontrolled posture. At an adult age, the FO group with early-life FS scored shorter periods of SWDs in amygdala EEG but without seizures and presented minor values of absolute power than the PO and CTRL groups. In adult rats, the long-term supplementation of FO minimizes the deleterious behavioral effects caused by early-life FS and decreases the occurrence and amplitude of SWDs in the EEG of the amygdala.
热性惊厥（FS）是一种常与异常脑电图活动（EEG）如棘波放电（SWD）相关的神经元紊乱。鱼油（FO）富含ω-3脂肪酸（θ-3），但其对FS改变的影响尚不清楚。本研究的目的是评估长期补充鱼油对早年患FS的成年雄性大鼠杏仁核脑电图的影响。从青春期到妊娠和分娩期间，将雌性Wistar祖代大鼠每天喂以补充了鱼油（FO）、棕榈油（PO）或去离子水（CTRL）的商业饮食。分娩后，雄性幼崽暴露于高温（HP）环境30分钟，然后回到母鼠身边。断奶后，幼崽喂以商业饮食并接受相应处理，直至155日龄时在杏仁核植入电极。在早年高温暴露期间，与FO组相比，PO组和CTRL组达到最高核心体温（CT）。此外，FO组仅有较少的肌阵挛，且采用失控姿势的潜伏期较长。成年后，早年患FS的FO组在杏仁核脑电图中SWD的发作时间较短，但无癫痫发作，且与PO组和CTRL组相比，绝对功率值较小。在成年大鼠中，长期补充鱼油可将早年患FS所导致的有害行为影响降至最低，并减少杏仁核脑电图中SWD的发生和幅度。
