Ruwisch Jannik, Welte Tobias, Prasse Antje
Dtsch Med Wochenschr. 2023 Jul;148(13):845-857. doi: 10.1055/a-1817-7887. Epub 2023 Jun 26.
Hemoptysis resembles a clinical emergency and necessitates a fast and well-coordinated diagnostic and therapeutic approach. While up to 50% of the underlying causes remain unidentified, the majority of cases in the western world can be attributed to respiratory infections and pulmonary neoplasm. While 10% of the patients present with massive, life-threatening hemoptysis, which require a timely airway protection in order to secure a sustained pulmonary gas-exchange, the vast majority presents with non-critical pulmonary bleeding events. Most critical pulmonary bleeding events arise from the bronchial circulation. An early chest imaging is key for identifying the bleeding cause and localization. While chest x-rays are widely implemented in the clinical work-flow and rapidly applicable, computed tomography and computed tomography angiography exhibit the highest diagnostic yield. Bronchoscopy can add diagnostic information especially in pathologies of the central airways, while offering multiple therapeutic options to maintain pulmonary gas exchange. The initial therapeutic regimen comprises early supportive care, but treatment of the underlying etiology is of prognostic relevance and avoids recurrent bleeding events. Bronchial arterial embolization usually is the therapy of choice in patients with massive hemoptysis, while definitive surgery is reserved for patients with refractory bleeding and complex pathologies.
咯血类似临床急症,需要快速且协调良好的诊断和治疗方法。虽然高达50%的潜在病因仍不明,但西方世界的大多数病例可归因于呼吸道感染和肺部肿瘤。10%的患者出现大量危及生命的咯血,需要及时进行气道保护以确保持续的肺气体交换,而绝大多数患者表现为非严重的肺出血事件。大多数严重的肺出血事件源于支气管循环。早期胸部影像学检查是确定出血原因和定位的关键。胸部X线在临床工作流程中广泛应用且快速可得,而计算机断层扫描和计算机断层扫描血管造影的诊断率最高。支气管镜检查尤其在中央气道病变中可增加诊断信息,同时提供多种维持肺气体交换的治疗选择。初始治疗方案包括早期支持治疗,但对潜在病因的治疗具有预后意义,可避免复发性出血事件。支气管动脉栓塞术通常是大量咯血患者的首选治疗方法,而确定性手术则适用于难治性出血和复杂病变的患者。