Duszenko M, Mecke D
Mol Biochem Parasitol. 1986 Jun;19(3):223-9. doi: 10.1016/0166-6851(86)90004-6.
Pentalenolactone (PL), an antibiotic produced by several strains of Streptomycetes, is a specific irreversible inhibitor of glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12). The effect of this antibiotic was studied in Trypanosoma brucei. In infected mice, due to the rapid metabolic inactivation of PL in vivo, trypanosomes were not affected by concentrations that were lethal to the host. Bloodstream trypanosomes in vitro were killed by low concentrations of PL (1.5 microgram ml-1), suggesting that there is no alternative to the glycolytic pathway for the generation of ATP in the bloodstream forms. In contrast, even high concentrations of PL (75 micrograms ml-1) were unable to inhibit growth of the procyclic form in vitro, presumably due to their ability to generate ATP independently of the glycolytic pathway.
戊内酯（PL）是由几种链霉菌菌株产生的一种抗生素，是甘油醛-3-磷酸脱氢酶（EC 1.2.1.12）的特异性不可逆抑制剂。在布氏锥虫中研究了这种抗生素的作用。在感染的小鼠中，由于PL在体内迅速代谢失活，锥虫不受对宿主致死浓度的影响。体外血流中的锥虫被低浓度的PL（1.5微克/毫升）杀死，这表明血流形式的锥虫在产生ATP方面没有糖酵解途径的替代途径。相比之下，即使是高浓度的PL（75微克/毫升）也无法在体外抑制前循环形式的生长，大概是因为它们能够独立于糖酵解途径产生ATP。
