Institute of Pharmaceutical Research, GLA University, Mathura, U.P, 281406, India.
Department of Computer Engineering & Applications, GLA University, Mathura, U.P, 281406, India.
Comb Chem High Throughput Screen. 2023;26(15):2668-2678. doi: 10.2174/1386207326666230627122630.
PCSK9 (proprotein convertase subtilisin/kexin type 9) is an enzyme that helps to reduce cardiovascular events. This clinical result is attributable primarily to the crucial involvement of PCSK9 in regulating the low-density lipoprotein cholesterol level. Because oral anti-PCSK9 medications have yet to be available, the benefits of this unique treatment approach have been diminished. Identifying naturally occurring PCSK9 inhibitors may lead to considerable progress in this regard. These inhibitors serve as a starting point for producing oral and effective components that could be used with statins to boost the proportion of patients who achieve their LDL-cholesterol goals. In this review, we have briefly summarised the recent information regarding natural components or extracts that have been shown to inhibit PCSK9 activity.
PCSK9（前蛋白转化酶枯草溶菌素 9）是一种有助于降低心血管事件的酶。这一临床结果主要归因于 PCSK9 在调节低密度脂蛋白胆固醇水平方面的关键作用。由于口服抗 PCSK9 药物尚未上市，这种独特治疗方法的益处已经减少。鉴定天然存在的 PCSK9 抑制剂可能会在这方面取得重大进展。这些抑制剂为生产口服有效成分提供了起点，这些成分可以与他汀类药物一起使用，提高达到 LDL-胆固醇目标的患者比例。在这篇综述中，我们简要总结了最近关于已显示抑制 PCSK9 活性的天然成分或提取物的信息。
