Bianchi Alexander, Baldi Alfonso, Farabini Andrea, Nibid Lorenzo, Roberti Vincenzo, Pellacani Giovanni, Kazakov Dmitry V, Donati Michele
Fondazione Policlinico Tor Vergata, Tor Vergata University, 81-00133 Rome, Italy.
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", 43-81100 Caserta, Italy.
Dermatopathology (Basel). 2023 May 31;10(2):147-152. doi: 10.3390/dermatopathology10020022.
Kissing nevus is a congenital melanocytic neoplasm arising in those parts of the body that split at some point during embryological development (i.e., eyelid; penis), resulting in two adjacent melanocytic nevi. To date, 23 cases of kissing nevus of the penis have been described, and dermatoscopic and histological findings are available in 4/23 cases. We report a dermatoscopic, histological and confocal microscopic analysis in a new case of the kissing nevus of the penis in a 57 years old man. Dermatoscopic analysis showed large globules in the central area and a peripheral pigment network; the histological examination confirmed the presence of an intradermal melanocytic nevus with minimal junctional component and congenital features. Moreover, we reported, for the first time, confocal microscopy findings in the kissing nevus of the penis, revealing the presence of dendritic cells in correspondence with the epidermis and suggesting a state of cellular activity. Considering the clinicopathological features of the lesion, a conservative approach was adopted, and a clinical follow-up was planned after six months.
接吻痣是一种先天性黑素细胞肿瘤，发生于胚胎发育过程中身体某些部位在某个阶段发生分裂的部位（即眼睑、阴茎），导致两个相邻的黑素细胞痣。迄今为止，已报道了23例阴茎接吻痣病例，其中4/23例有皮肤镜和组织学检查结果。我们报告了一例57岁男性阴茎接吻痣新病例的皮肤镜、组织学和共聚焦显微镜分析。皮肤镜分析显示中央区域有大的球状结构和周边色素网；组织学检查证实为真皮内黑素细胞痣，交界成分极少且具有先天性特征。此外，我们首次报告了阴茎接吻痣的共聚焦显微镜检查结果，发现在与表皮对应的部位存在树突状细胞，提示细胞处于活跃状态。考虑到病变的临床病理特征，采取了保守治疗方法，并计划在六个月后进行临床随访。
