胶质母细胞瘤免疫治疗研究中的转化模型。
Translational Models in Glioma Immunotherapy Research.
机构信息
School of Medicine, Stanford University, Stanford, CA 94305, USA.
Department of Neurosurgery, Stanford University Medical Center, Stanford, CA 94304, USA.
出版信息
Curr Oncol. 2023 Jun 11;30(6):5704-5718. doi: 10.3390/curroncol30060428.
Immunotherapy is a promising therapeutic domain for the treatment of gliomas. However, clinical trials of various immunotherapeutic modalities have not yielded significant improvements in patient survival. Preclinical models for glioma research should faithfully represent clinically observed features regarding glioma behavior, mutational load, tumor interactions with stromal cells, and immunosuppressive mechanisms. In this review, we dive into the common preclinical models used in glioma immunology, discuss their advantages and disadvantages, and highlight examples of their utilization in translational research.
免疫疗法是治疗神经胶质瘤的一个有前途的治疗领域。然而，各种免疫治疗方式的临床试验并未显著提高患者的生存率。神经胶质瘤研究的临床前模型应忠实地反映神经胶质瘤行为、突变负荷、肿瘤与基质细胞相互作用以及免疫抑制机制等方面的临床观察特征。在这篇综述中，我们深入探讨了神经胶质瘤免疫学中常用的临床前模型，讨论了它们的优缺点，并强调了它们在转化研究中的应用实例。
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