Center for Terahertz Waves, Key Laboratory of Optoelectronics Information and Technology, Ministry of Education, Tianjin University, Tianjin 300072, China.
School of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
Biosensors (Basel). 2023 Jun 2;13(6):606. doi: 10.3390/bios13060606.
Terahertz spectroscopy is a powerful tool for investigating the properties and states of biological matter. Here, a systematic investigation of the interaction of THz wave with "bright mode" resonators and "dark mode" resonators has been conducted, and a simple general principle of obtaining multiple resonant bands has been developed. By manipulating the number and positions of bright mode and dark mode resonant elements in metamaterials, we realized multi-resonant bands terahertz metamaterial structures with three electromagnetic-induced transparency in four-frequency bands. Different carbohydrates in the state of dried films were selected for detection, and the results showed that the multi-resonant bands metamaterial have high response sensitivity at the resonance frequency similar to the characteristic frequency of the biomolecule. Furthermore, by increasing the biomolecule mass in a specific frequency band, the frequency shift in glucose was found to be larger than that of maltose. The frequency shift in glucose in the fourth frequency band is larger than that of the second band, whereas maltose exhibits an opposing trend, thus enabling recognition of maltose and glucose. Our findings provide new insights into the design of functional multi-resonant bands metamaterials, as well as new strategies for developing multi-band metamaterial biosensing devices.
太赫兹光谱学是研究生物物质性质和状态的有力工具。在这里，我们对太赫兹波与“亮模式”谐振器和“暗模式”谐振器的相互作用进行了系统的研究，并提出了一种获得多个谐振带的简单通用原理。通过操纵超材料中亮模式和暗模式谐振元件的数量和位置，我们实现了具有四个频带中三个电磁感应透明的多谐振带太赫兹超材料结构。选择干燥膜状态下的不同碳水化合物进行检测，结果表明，多谐振带超材料在与生物分子特征频率相似的共振频率处具有高响应灵敏度。此外，通过在特定频带中增加生物分子质量，发现葡萄糖的频移大于麦芽糖。在第四频带中葡萄糖的频移大于第二频带，而麦芽糖则呈现相反的趋势，从而能够识别麦芽糖和葡萄糖。我们的研究结果为多功能多谐振带超材料的设计提供了新的思路，同时也为开发多频带超材料生物传感器件提供了新的策略。
