使用抗淋巴细胞球蛋白（ALG）和供体血小板对犬肾同种异体移植物进行主动增强。
Active enhancement of dog kidney allografts using ALG and donor platelets.
作者信息
Rowiński W, Ryffa T, Stepkowski S, Woźniewicz B, Ruka M, Wasowska B, Hay M, Olszewski W
出版信息
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):1013-9.
The results of the studies indicate that platelets can be used as donor specific antigen in protocols of "biological suppression". Administration of donor specific platelets 10 days after transplantation to unmatched mongrel dogs treated for a brief period with ALG resulted in a marked prolongation of kidney allograft survival. Acute rejection of a second kidney from an indifferent donor suggests that a state of specific unresponsiveness was achieved by recipients pretreatment with ALG and donor antigen challenge.
研究结果表明，血小板可作为“生物抑制”方案中的供体特异性抗原。在移植后10天，将供体特异性血小板给予用抗淋巴细胞球蛋白（ALG）进行短期治疗的不匹配杂种犬，可显著延长肾移植存活时间。来自无关供体的第二个肾脏发生急性排斥反应，提示受体经ALG预处理和供体抗原刺激后达到了特异性无反应状态。
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