Key Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Medicine, Linyi University, Linyi 276005, China.
Biosensors (Basel). 2023 Jun 12;13(6):642. doi: 10.3390/bios13060642.
Photothermal therapy (PTT) has received constant attention as a promising cancer treatment. However, PTT-induced inflammation can limit its effectiveness. To address this shortcoming, we developed second near-infrared (NIR-II) light-activated nanotheranostics (CPNPBs), which include a thermosensitive nitric oxide (NO) donor (BNN6) to enhance PTT. Under a 1064 nm laser irradiation, the conjugated polymer in CPNPBs serves as a photothermal agent for photothermal conversion, and the generated heat triggers the decomposition of BNN6 to release NO. The combination of hyperthermia and NO generation under single NIR-II laser irradiation allows enhanced thermal ablation of tumors. Consequently, CPNPBs can be exploited as potential candidates for NO-enhanced PTT, holding great promise for their clinical translational development.
光热治疗（PTT）作为一种有前途的癌症治疗方法受到了持续关注。然而，PTT 诱导的炎症会限制其效果。为了解决这一缺点，我们开发了第二代近红外（NIR-II）光激活纳米治疗剂（CPNPBs），其中包括一种热敏性一氧化氮（NO）供体（BNN6）以增强 PTT。在 1064nm 激光照射下，CPNPBs 中的共轭聚合物作为光热转换的光热剂，产生的热量触发 BNN6 的分解以释放 NO。在单一 NIR-II 激光照射下，高热和 NO 生成的结合允许增强肿瘤的热消融。因此，CPNPBs 可用作增强 PTT 的潜在候选物，具有很大的临床转化发展潜力。
