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用于伤口敷料的高含水量含天然活性剂多孔水凝胶片的研制。

Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings.

作者信息

Pinthong Thanyaporn, Yooyod Maytinee, Daengmankhong Jinjutha, Tuancharoensri Nantaprapa, Mahasaranon Sararat, Viyoch Jarupa, Jongjitwimol Jirapas, Ross Sukunya, Ross Gareth M

机构信息

Biopolymer Group, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.

Biopolymer Group, Department of Chemistry, Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.

出版信息

Gels. 2023 Jun 3;9(6):459. doi: 10.3390/gels9060459.


DOI:10.3390/gels9060459
PMID:37367130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10298319/
Abstract

This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional components were added (acid, blowing agent, foam stabilizer). Manuka honey (MH) was also incorporated at concentrations of 1 and 10% /. The hydrogel samples were characterized for morphology via scanning electron microscopy, mechanical rheology, swelling using a gravimetric method, surface absorption, and cell cytotoxicity. The results confirmed the formation of porous hydrogels (PH) with pore sizes ranging from ~50-110 µm. The swelling performance showed that the non-porous hydrogel (NPH) swelled to ~2000%, while PH weight increased ~5000%. Additionally, the use of a surface absorption technique showed that the PH absorbed 10 μL in <3000 ms, and NPH absorbed <1 μL over the same time. Incorporating MH the enhanced gel appearance and mechanical properties, including smaller pores and linear swelling. In summary, the PH produced in this study had excellent swelling performance with rapid absorption of surface liquid. Therefore, these materials have the potential to expand the applicability of hydrogels to a range of wound types, as they can both donate and absorb fluid.

摘要

这项工作致力于制备一种适用于中重度渗出性伤口的多孔水凝胶系统,而传统水凝胶在此类伤口中无法使用。这些水凝胶以2-丙烯酰胺基-2-甲基丙烷磺酸(AMPs)为基础。为了产生多孔结构,添加了额外的成分(酸、发泡剂、泡沫稳定剂)。麦卢卡蜂蜜(MH)也以1%和10%的浓度加入。通过扫描电子显微镜对水凝胶样品的形态、机械流变学、采用重量法的溶胀、表面吸收和细胞毒性进行了表征。结果证实形成了孔径范围约为50 - 110 µm的多孔水凝胶(PH)。溶胀性能表明,无孔水凝胶(NPH)溶胀至约2000%,而PH的重量增加约5000%。此外,表面吸收技术的使用表明,PH在<3000毫秒内吸收10 μL,而NPH在相同时间内吸收<1 μL。加入MH增强了凝胶的外观和机械性能,包括更小的孔隙和线性溶胀。总之,本研究中制备的PH具有优异的溶胀性能和快速吸收表面液体的能力。因此,这些材料有可能将水凝胶的适用性扩展到一系列伤口类型,因为它们既能释放又能吸收液体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/f7177a86c765/gels-09-00459-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/1416a9d62042/gels-09-00459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/e0309fae0fd0/gels-09-00459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/bebb26a8b6ac/gels-09-00459-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/91117fbe2ded/gels-09-00459-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/ad05b9b9d67e/gels-09-00459-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/b5fe115a1b3c/gels-09-00459-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/e7ef1db26a64/gels-09-00459-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/00ab55149474/gels-09-00459-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/a076bbd58afd/gels-09-00459-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/f7177a86c765/gels-09-00459-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/1416a9d62042/gels-09-00459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/e0309fae0fd0/gels-09-00459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/bebb26a8b6ac/gels-09-00459-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/91117fbe2ded/gels-09-00459-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/ad05b9b9d67e/gels-09-00459-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/b5fe115a1b3c/gels-09-00459-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/e7ef1db26a64/gels-09-00459-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/00ab55149474/gels-09-00459-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/a076bbd58afd/gels-09-00459-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b488/10298319/f7177a86c765/gels-09-00459-g010.jpg

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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本文引用的文献

[1]
Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release.

Gels. 2023-4-14

[2]
Porous Hydrogels: Present Challenges and Future Opportunities.

Langmuir. 2023-2-14

[3]
The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application.

Int J Mol Sci. 2021-11-6

[4]
Modern Wound Dressings: Hydrogel Dressings.

Biomedicines. 2021-9-16

[5]
Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing.

Biomacromolecules. 2021-9-13

[6]
Nanomaterials in Wound Healing and Infection Control.

Antibiotics (Basel). 2021-4-21

[7]
Manuka honey microneedles for enhanced wound healing and the prevention and/or treatment of Methicillin-resistant Staphylococcus aureus (MRSA) surgical site infection.

Sci Rep. 2020-8-6

[8]
Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances.

Tissue Eng Part B Rev. 2020-6

[9]
Dissecting the Antimicrobial Composition of Honey.

Antibiotics (Basel). 2019-12-5

[10]
Hydrogels: soft matters in photomedicine.

Photochem Photobiol Sci. 2019-8-28

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