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基于N-乙烯基甲酰胺的均聚物和共聚物水凝胶：水结构对控释影响的研究

Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release.

作者信息

Yooyod Maytinee, Ross Sukunya, Phewchan Premchirakorn, Daengmankhong Jinjutha, Pinthong Thanyaporn, Tuancharoensri Nantaprapa, Mahasaranon Sararat, Viyoch Jarupa, Ross Gareth M

机构信息

Biopolymer Group, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.

Biopolymer Group, Department of Chemistry, Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.

出版信息

Gels. 2023 Apr 14;9(4):333. doi: 10.3390/gels9040333.

DOI:10.3390/gels9040333
PMID:37102945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10138162/
Abstract

This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The hydrogels were analyzed for important properties such as equilibrium water content (%EWC), contact angle, freezing and non-freezing water, and diffusion-based in vitro release. The results showed that PNVF had an extremely high %EWC of 94.57%, while a decreasing NVF content in the copolymer hydrogels led to a decrease in water content with a linear relationship with HEA or CEA content. Water structuring in the hydrogels showed appreciably more variance, with ratios of free to bound water differing from 16.7:1 (NVF) to 1.3:1 (CEA), corresponding to PNVF having ~67 water molecules per repeat unit. The release studies of different dye molecules followed Higuchi's model, with the amount of dye released from the hydrogels depending on the amount of free water and the structural interactions between the polymer and the molecule being released. The results suggest that PNVF copolymer hydrogels have potential for controlled drug delivery by altering the polymer composition to govern the amount and ratio of free to bound water contained in the hydrogels.

摘要

本研究考察了基于聚（N-乙烯基甲酰胺）（PNVF）、N-乙烯基甲酰胺与N-羟乙基丙烯酰胺（HEA）的共聚物（P（NVF-co-HEA））以及丙烯酸2-羧乙酯（CEA）（P（NVF-co-CEA））的新型水凝胶的性能，这些水凝胶是使用紫外发光二极管（UVLED）光源通过光聚合反应合成的。对这些水凝胶的重要性能进行了分析，如平衡含水量（%EWC）、接触角、冻结水和非冻结水以及基于扩散的体外释放。结果表明，PNVF的平衡含水量极高，为94.57%，而共聚物水凝胶中NVF含量的降低导致含水量降低，且与HEA或CEA含量呈线性关系。水凝胶中的水结构表现出明显更多的变化，自由水与结合水的比例从16.7:1（NVF）到1.3:1（CEA）不等，这对应于PNVF每个重复单元约有67个水分子。不同染料分子的释放研究遵循Higuchi模型，从水凝胶中释放的染料量取决于自由水的量以及聚合物与被释放分子之间的结构相互作用。结果表明，PNVF共聚物水凝胶通过改变聚合物组成来控制水凝胶中自由水与结合水的量和比例，具有用于控释药物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/41921481d186/gels-09-00333-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/7778aea7ec4e/gels-09-00333-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/b6a52950d473/gels-09-00333-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/8ef93d743bb4/gels-09-00333-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/27d376e60011/gels-09-00333-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/598d3cc648eb/gels-09-00333-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/7377f1d2dadc/gels-09-00333-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/7b342b748600/gels-09-00333-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/86fe69f2e6d8/gels-09-00333-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/41921481d186/gels-09-00333-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/7778aea7ec4e/gels-09-00333-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/b6a52950d473/gels-09-00333-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/8ef93d743bb4/gels-09-00333-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/27d376e60011/gels-09-00333-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/598d3cc648eb/gels-09-00333-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/7377f1d2dadc/gels-09-00333-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/7b342b748600/gels-09-00333-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/86fe69f2e6d8/gels-09-00333-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ca3/10138162/41921481d186/gels-09-00333-g009.jpg

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