Zainuddin Andik Nisa Zahra, Mustakim Nurul Nadhirah, Rosemanzailani Farah Alea, Fadilah Nur Izzah Md, Maarof Manira, Fauzi Mh Busra
Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.
Advance Bioactive Materials-Cells UKM Research Group, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
Gels. 2025 Mar 12;11(3):194. doi: 10.3390/gels11030194.
Honey has long been recognized for its medicinal properties, particularly in wound healing. Recent advancements in material science have led to the development of honey-containing hydrogels, combining the natural healing properties of honey with the versatile characteristics of hydrogel matrices. These hydrogels offer numerous advantages, including high moisture retention, biocompatibility, and the controlled release of bioactive compounds, making them highly effective for wound healing applications. Hydrogels hold significant potential in advancing medical applications, particularly for cutaneous injuries. The diverse properties of honey, including antimicrobial, anti-inflammatory, and anti-eschar effects, have shown promise in accelerating tissue regeneration. According to studies, they are effective in maintaining a good swelling ratio index, Water Vapour Transmission Rate (WVTR), contact angle, tensile and elongation at break, in vitro biodegradation rate, viscosity and porosity analysis, lowering bacterial infections, and encouraging rapid tissue regeneration with notable FTIR peaks and SEM average pore sizes. However, limitations such as low bioavailability and inefficiencies in direct application reduce their therapeutic effectiveness at the wound site. Integrating honey into hydrogels can help preserve its wound healing mechanisms while enhancing its ability to facilitate skin tissue recovery. This review explores the underlying mechanisms of honey in wound healing management and presents an extensive analysis of honey-containing hydrogels reported in the literature over the past eight years. It emphasizes the physicochemical and mechanical effectiveness and advancements of honey-incorporated hydrogels in promoting skin wound healing and tissue regeneration, supported by evidence from both in vitro and in vivo studies. While honey-based therapies for wound healing have demonstrated promising outcomes in numerous in vitro and animal studies, clinical studies remain limited. Despite that, honey's incorporation into hydrogel systems, however, offers a potent fusion of contemporary material technology and natural healing qualities, marking a substantial breakthrough in wound treatment.
长期以来，蜂蜜因其药用特性而受到认可，尤其是在伤口愈合方面。材料科学的最新进展促使了含蜂蜜水凝胶的开发，它将蜂蜜的天然愈合特性与水凝胶基质的多种特性结合在一起。这些水凝胶具有许多优点，包括高保湿性、生物相容性以及生物活性化合物的控释性，使其在伤口愈合应用中非常有效。水凝胶在推进医学应用方面具有巨大潜力，特别是对于皮肤损伤。蜂蜜的多种特性，包括抗菌、抗炎和抗焦痂作用，已显示出在加速组织再生方面的前景。根据研究，它们在维持良好的肿胀率指数、水蒸气透过率（WVTR）、接触角、拉伸强度和断裂伸长率、体外生物降解率、粘度和孔隙率分析方面有效，可降低细菌感染，并通过显著的傅里叶变换红外光谱（FTIR）峰和扫描电子显微镜（SEM）平均孔径促进快速组织再生。然而，诸如低生物利用度和直接应用效率低下等局限性降低了它们在伤口部位的治疗效果。将蜂蜜整合到水凝胶中有助于保留其伤口愈合机制，同时增强其促进皮肤组织恢复的能力。本综述探讨了蜂蜜在伤口愈合管理中的潜在机制，并对过去八年文献中报道的含蜂蜜水凝胶进行了广泛分析。它强调了含蜂蜜水凝胶在促进皮肤伤口愈合和组织再生方面的物理化学和机械有效性及进展，这得到了体外和体内研究证据的支持。虽然基于蜂蜜的伤口愈合疗法在众多体外和动物研究中已显示出有前景的结果，但临床研究仍然有限。尽管如此，将蜂蜜纳入水凝胶系统提供了当代材料技术与天然愈合特性的有力融合，标志着伤口治疗取得了重大突破。
