Gąsior Gabriela, Grodzicka Marlena, Jędrzejewski Tomasz, Wiśniewski Marek, Radtke Aleksandra
Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina Street 7, 87-100 Toruń, Poland.
Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Lwowska Street 1, 87-100 Toruń, Poland.
J Funct Biomater. 2023 May 24;14(6):293. doi: 10.3390/jfb14060293.
Biodegradable metal systems are the future of modern implantology. This publication describes the preparation of porous iron-based materials using a simple, affordable replica method on a polymeric template. We obtained two iron-based materials with different pore sizes for potential application in cardiac surgery implants. The materials were compared in terms of their corrosion rate (using immersion and electrochemical methods) and their cytotoxic activity (indirect test on three cell lines: mouse L929 fibroblasts, human aortic smooth muscle cells (HAMSC), and human umbilical vein endothelial cells (HUVEC)). Our research proved that the material being too porous might have a toxic effect on cell lines due to rapid corrosion.
可生物降解金属系统是现代植入术的未来。本出版物描述了使用一种简单、经济的复制方法在聚合物模板上制备多孔铁基材料的过程。我们获得了两种具有不同孔径的铁基材料，用于心脏手术植入物的潜在应用。对这些材料在腐蚀速率（采用浸泡和电化学方法）和细胞毒性活性（对三种细胞系进行间接测试：小鼠L929成纤维细胞、人主动脉平滑肌细胞（HAMSC）和人脐静脉内皮细胞（HUVEC））方面进行了比较。我们的研究证明，由于快速腐蚀，孔隙过多的材料可能对细胞系产生毒性作用。
