亚致死剂量和致死剂量照射小鼠中异种上皮细胞诱导骨形成的尝试。初步报告。
Attempts of bone induction by xenogeneic epithelial cells in sublethally and lethally irradiated mice. Preliminary report.
作者信息
Włodarski K, Jakóbisiak M
出版信息
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):1047-51.
Contrary to non-irradiated mice, no heterotopic bone formation was observed in sublethally (700 R) irradiated animals. In animals lethally irradiated (850 R) and protected with syngeneic bone marrow, a bone induction can be observed. The induction is weaker and infrequent when inducing cells are administered 2 weeks after irradiation and repopulation, and a cortisone was given at the time of epithelial cell grafting, than when the inducing cells were given immediately after irradiation and repopulation, and no cortisone was administered.
与未受辐照的小鼠相反，在接受亚致死剂量（700拉德）辐照的动物中未观察到异位骨形成。在接受致死剂量（850拉德）辐照并用同基因骨髓保护的动物中，可以观察到骨诱导现象。与在辐照和再植后立即给予诱导细胞且未给予可的松相比，在辐照和再植2周后给予诱导细胞且在上皮细胞移植时给予可的松时，诱导作用较弱且不常见。
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