O'Brien Barry, Reilly John, Coffey Ken, González-Suárez Ana, Quinlan Leo, van Zyl Martin
AtriAN Medical Ltd., Unit 204, Business Innovation Centre, Upper Newcastle, H91 W60E Galway, Ireland.
School of Engineering, University of Galway, H91 TK33 Galway, Ireland.
J Cardiovasc Dev Dis. 2023 May 29;10(6):238. doi: 10.3390/jcdd10060238.
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and propagation of AF. This paper reviews the background and development of a unique cardioneuroablation technique for the modulation of the cardiac ANS as a potential treatment for AF. The treatment uses pulsed electric field energy to selectively electroporate ANS structures on the epicardial surface of the heart. Insights from in vitro studies and electric field models are presented as well as data from both pre-clinical and early clinical studies.
心房颤动（AF）是影响全球数百万人的最常见心律失常。心脏自主神经系统（ANS）在房颤的发生和传播中起着关键作用，这一点已得到广泛认可。本文回顾了一种独特的心神经消融技术的背景和发展，该技术用于调节心脏自主神经系统，作为房颤的一种潜在治疗方法。该治疗使用脉冲电场能量选择性地使心脏心外膜表面的自主神经结构发生电穿孔。文中介绍了体外研究和电场模型的见解，以及临床前和早期临床研究的数据。
