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不可逆电穿孔用于心房颤动导管消融的生物物理学与临床疗效

Biophysics and Clinical Effectiveness of Irreversible Electroporation for Catheter Ablation of Atrial Fibrillation.

作者信息

Eberl Anna-Sophie, Plank Gernot, Manninger Martin, Rohrer Ursula, Stix Laura, Kurath-Koller Stefan, Zirlik Andreas, Scherr Daniel

机构信息

Division of Cardiology, Medical University Graz, 8036 Graz, Austria.

Department of Physics and Biophysics, Medical University Graz, 8036 Graz, Austria.

出版信息

J Cardiovasc Dev Dis. 2025 Jun 7;12(6):218. doi: 10.3390/jcdd12060218.

DOI:10.3390/jcdd12060218
PMID:40558653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12194562/
Abstract

Understanding the biophysics of electroporation-the mechanism by which pulsed electric fields achieve tissue ablation-is essential for advancing this emerging technology. In this review, we summarize key publications from past years to provide an overview of current knowledge and future perspectives. We discuss the fundamental principles of PFA at the cellular, physical, and technical levels, along with its potential benefits and limitations. A deeper understanding of these biophysical mechanisms and the parameters required to create durable lesions may contribute to improved clinical outcomes and drive future innovation.

摘要

了解电穿孔的生物物理学——脉冲电场实现组织消融的机制——对于推动这项新兴技术至关重要。在本综述中，我们总结了过去几年的关键出版物，以概述当前的知识和未来的前景。我们在细胞、物理和技术层面讨论了脉冲电场消融（PFA）的基本原理，以及其潜在的益处和局限性。对这些生物物理机制以及产生持久损伤所需参数的更深入理解可能有助于改善临床结果并推动未来的创新。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/b8e3d51c7085/jcdd-12-00218-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/d8b47f34f803/jcdd-12-00218-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/fe4747e12301/jcdd-12-00218-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/a90d00f52b64/jcdd-12-00218-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/b8e3d51c7085/jcdd-12-00218-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/d8b47f34f803/jcdd-12-00218-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/fe4747e12301/jcdd-12-00218-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/a90d00f52b64/jcdd-12-00218-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6405/12194562/b8e3d51c7085/jcdd-12-00218-g004.jpg

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本文引用的文献

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Heart Rhythm O2. 2024 Dec 5;6(3):350-361. doi: 10.1016/j.hroo.2024.11.025. eCollection 2025 Mar.
2
Catheter ablation using pulsed-field energy: Advantages and limitations compared with conventional energy.使用脉冲场能量的导管消融：与传统能量相比的优势和局限性
J Arrhythm. 2025 Feb 4;41(1):e70011. doi: 10.1002/joa3.70011. eCollection 2025 Feb.
3
Effect of Sequential, Colocalized Radiofrequency and Pulsed Field Ablation on Cardiac Lesion Size and Histology.
序贯、共定位射频与脉冲场消融对心脏损伤大小及组织学的影响
Circ Arrhythm Electrophysiol. 2025 Feb;18(2):e013143. doi: 10.1161/CIRCEP.124.013143. Epub 2025 Jan 24.
4
First-in-human trial of atrial fibrillation ablation using real-time tissue optical assessment to predict pulsed field lesion durability.使用实时组织光学评估预测脉冲场损伤耐久性的心房颤动消融首次人体试验。
Europace. 2025 Feb 5;27(2). doi: 10.1093/europace/euaf009.
5
Repeat procedures after pulsed field ablation for atrial fibrillation: MANIFEST-REDO study.心房颤动脉冲场消融术后重复手术：MANIFEST-REDO研究
Europace. 2025 Aug 4;27(8). doi: 10.1093/europace/euaf012.
6
LA PULSE: Evaluating Left Atrial Function Pre- and Post-Atrial Fibrillation Ablation Using PULSEd Field Ablation.LA PULSE：使用脉冲电场消融评估心房颤动消融术前和术后的左心房功能。
J Clin Med. 2024 Dec 26;14(1):68. doi: 10.3390/jcm14010068.
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Circ Arrhythm Electrophysiol. 2024 Dec;17(12):e013208. doi: 10.1161/CIRCEP.124.013208. Epub 2024 Nov 29.
8
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Coronary Spasm Due to Pulsed Field Ablation: A State-of-the-Art Review.
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