通过改良的小鼠迁移抑制试验检测新鲜和保存的皮质及松质同种异体骨移植物的免疫原性。
Immunogenicity of fresh and preserved cortical and cancellous allogeneic bone grafts as tested by modified migration inhibition test in mice.
作者信息
Kamińska G, Kamiński M, Komender A
出版信息
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):1053-7.
PMID:373675
Abstract
Mice were grafted with allogeneic compact and cancellous bone. The bone used was fresh and preserved by either lyophilization or deep freezing. Preserved grafts were radiosterilized by a dose of 3.3 MRads. The immunization of recipients was assessed by a modified migration inhibition test based on migration of cells from three-dimensional clot culture. Both preservation methods seem to change bone immunogenicity and enhancement of migration instead of inhibition occurring in the case of fresh bone was noted.
摘要
将同种异体密质骨和松质骨移植到小鼠体内。所用的骨是新鲜的，通过冻干或深度冷冻保存。保存的移植物用3.3兆拉德的剂量进行辐射灭菌。通过基于三维凝块培养的细胞迁移的改良迁移抑制试验评估受体的免疫反应。两种保存方法似乎都改变了骨的免疫原性，并且注意到与新鲜骨的情况相比，出现的是迁移增强而不是抑制。
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