Bianco Monica E, Vu My H, Bain James R, Muehlbauer Michael J, Ilkayeva Olga R, Scholtens Denise M, Josefson Jami, Lowe William L
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Metabolites. 2023 Jun 13;13(6):749. doi: 10.3390/metabo13060749.
Maternal metabolites influence the size of newborns independently of maternal body mass index (BMI) and glycemia, highlighting the importance of maternal metabolism on offspring outcomes. This study examined associations of maternal metabolites during pregnancy with childhood adiposity, and cord blood metabolites with childhood adiposity using phenotype and metabolomic data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and the HAPO Follow-Up Study. The maternal metabolites analyses included 2324 mother-offspring pairs, while the cord blood metabolites analyses included 937 offspring. Multiple logistic and linear regression were used to examine associations between primary predictors, maternal or cord blood metabolites, and childhood adiposity outcomes. Multiple maternal fasting and 1 hr metabolites were significantly associated with childhood adiposity outcomes in Model 1 but were no longer significant after adjusting for maternal BMI and/or maternal glycemia. In the fully adjusted model, fasting lactose levels were negatively associated with child BMI z-scores and waist circumference, while fasting urea levels were positively associated with waist circumference. One-hour methionine was positively associated with fat-free mass. There were no significant associations between cord blood metabolites and childhood adiposity outcomes. Few metabolites were associated with childhood adiposity outcomes after adjusting for maternal BMI and glucose, suggesting that maternal BMI accounts for the association between maternal metabolites and childhood adiposity.
母体代谢产物独立于母体体重指数（BMI）和血糖水平影响新生儿的大小，凸显了母体代谢对后代结局的重要性。本研究利用高血糖与不良妊娠结局（HAPO）研究及HAPO随访研究中的表型和代谢组学数据，检测孕期母体代谢产物与儿童肥胖之间的关联，以及脐血代谢产物与儿童肥胖之间的关联。母体代谢产物分析纳入了2324对母婴，而脐血代谢产物分析纳入了937名后代。采用多元逻辑回归和线性回归分析主要预测因素（母体或脐血代谢产物）与儿童肥胖结局之间的关联。在模型1中，多种母体空腹和1小时代谢产物与儿童肥胖结局显著相关，但在调整母体BMI和/或母体血糖后不再显著。在完全调整模型中，空腹乳糖水平与儿童BMI z评分和腰围呈负相关，而空腹尿素水平与腰围呈正相关。1小时蛋氨酸水平与去脂体重呈正相关。脐血代谢产物与儿童肥胖结局之间无显著关联。在调整母体BMI和血糖后，几乎没有代谢产物与儿童肥胖结局相关，这表明母体BMI解释了母体代谢产物与儿童肥胖之间的关联。
