School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Zhejiang A&F University, Hangzhou, China.
Funct Integr Genomics. 2023 Jun 27;23(3):212. doi: 10.1007/s10142-023-01147-4.
In recent years, significant progress has been made in understanding the biosynthetic pathway and regulation of flavonoids through forward genetic approaches. However, there remains a notable gap in knowledge regarding the functional characterization and underlying processes of the transport framework responsible for flavonoid transport. This aspect requires further investigation and clarification to achieve a comprehensive understanding. Presently, there are a total of four proposed transport models associated with flavonoids, namely glutathione S-transferase (GST), multidrug and toxic compound extrusion (MATE), multidrug resistance-associated protein (MRPs), and bilitranslocase-homolog (BTL). Extensive research has been conducted on the proteins and genes related to these transport models. However, despite these efforts, numerous challenges still exist, leaving much to be explored in the future. Gaining a deeper understanding of the mechanisms underlying these transport models holds immense potential for various fields such as metabolic engineering, biotechnological approaches, plant protection, and human health. Therefore, this review aims to provide a comprehensive overview of recent advancements in the understanding of flavonoid transport mechanisms. By doing so, we aim to paint a clear and coherent picture of the dynamic trafficking of flavonoids.
近年来，通过正向遗传学方法，人们在理解类黄酮的生物合成途径和调控方面取得了重大进展。然而，对于负责类黄酮运输的运输框架的功能表征和潜在过程，仍存在明显的知识空白。这方面需要进一步的调查和澄清，以实现全面的理解。目前，共有四种与类黄酮相关的拟议运输模型，即谷胱甘肽 S-转移酶 (GST)、多药和毒性化合物外排 (MATE)、多药耐药相关蛋白 (MRPs) 和胆红素转运体同源物 (BTL)。已经对与这些运输模型相关的蛋白质和基因进行了广泛的研究。然而，尽管做出了这些努力，仍然存在许多挑战，未来仍有许多需要探索。深入了解这些运输模型的机制具有巨大的潜力，可应用于代谢工程、生物技术方法、植物保护和人类健康等各个领域。因此，本综述旨在全面概述理解类黄酮运输机制的最新进展。通过这样做，我们旨在描绘类黄酮动态运输的清晰而连贯的画面。
