Kim Yeonhwa, Kim Seong Soon, Park Byeong Heon, Hwang Kyu-Seok, Bae Myung Ae, Cho Sung-Hee, Kim Suhyun, Park Hae-Chul
Zebrafish Translational Medical Research Center, Korea University, Ansan 15588, Republic of Korea.
Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34141, Republic of Korea.
Toxics. 2023 May 24;11(6):477. doi: 10.3390/toxics11060477.
Bisphenol F (BPF; 4,4'-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.
双酚F（BPF；4,4'-二羟基二苯甲烷）是塑料和环氧树脂制造中最常用的化合物之一。先前的研究表明，BPF会影响斑马鱼的运动行为、氧化应激和神经发育。然而，其神经毒性作用存在争议，潜在机制尚不清楚。为了确定BPF是否影响运动系统，我们将斑马鱼胚胎暴露于BPF中，并评估行为、组织学和神经化学变化。与对照幼虫相比，经BPF处理的斑马鱼幼虫的自发运动行为和惊吓反应显著降低。BPF诱导斑马鱼幼虫运动退化和髓鞘形成缺陷。此外，胚胎期暴露于BPF会导致神经化学物质（包括神经递质和神经甾体）的代谢谱改变，这可能会影响运动和运动功能。总之，暴露于BPF有可能影响斑马鱼幼虫的存活、运动轴突长度、运动活性、髓鞘形成和神经化学水平。
