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肾移植患者的淋巴细胞依赖性抗体(LDA)检测

Lymphocyte dependent antibody (LDA) test in renal transplanted patients.

作者信息

Wojtulewicz-Kurkus J, Podobińska I, Rowińska D, Lao M, Gutowska-Jablońska M, Orłowski T

出版信息

Arch Immunol Ther Exp (Warsz). 1978;26(1-6):991-5.

PMID:373697
Abstract

Using LDA test the presence of antibodies in patients prior to and post renal transplantation was studied. The relationship between the results of LDA test and graft rejection episodes, the treatment with large doses of prednisolone and CDC test performed simultaneously were analized. No correlation between results of LDA test prior to transplantation or its response to prednisolone treatment and acute rejection crises was found. The value of LDA test in predicting rejection episodes was not confirmed. LDA test detects antibodies 10 times more frequently than CDC test. The presence of cytotoxic antibodies CDC was not always connected with the presence of LDA and vice versa.

摘要

使用淋巴细胞毒性抗体(LDA)检测研究肾移植患者移植前后抗体的存在情况。分析了LDA检测结果与移植排斥反应发作、大剂量泼尼松龙治疗以及同时进行的补体依赖细胞毒试验(CDC)之间的关系。未发现移植前LDA检测结果或其对泼尼松龙治疗的反应与急性排斥反应危机之间存在相关性。LDA检测在预测排斥反应发作方面的价值未得到证实。LDA检测比CDC检测更频繁地检测到抗体10倍。细胞毒性抗体CDC的存在并不总是与LDA的存在相关,反之亦然。

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