Baker R E, van der Togt C
Neurosci Lett. 1986 Jun 30;67(3):285-8. doi: 10.1016/0304-3940(86)90323-x.
Sensory afferent projection patterns within organotypic explants of fetal mouse spinal cord-dorsal root ganglia (SC-DRG) were mapped out histologically using an HRP-staining method. Cultures grown in tetrodotoxin-containing medium with added gangliosides, in contrast to those grown without the addition of these compounds, showed preferential DRG innervation of the dorsal half of the cord. It therefore appears that gangliosides can compensate for the absence of functional activity during the development of selective innervation patterns.
利用辣根过氧化物酶（HRP）染色法，通过组织学方法描绘了胎鼠脊髓-背根神经节（SC-DRG）器官型外植体内的感觉传入投射模式。与未添加这些化合物的培养物相比，在含有河豚毒素并添加神经节苷脂的培养基中生长的培养物显示出脊髓背侧半部分有优先的背根神经节神经支配。因此，神经节苷脂似乎可以在选择性神经支配模式发育过程中弥补功能活动的缺失。
