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噬菌体鸡尾酒与多种抗菌剂联合使用以防止噬菌体抗性的出现。

The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance.

作者信息

Duc Hoang Minh, Zhang Yu, Hoang Son Minh, Masuda Yoshimitsu, Honjoh Ken-Ichi, Miyamoto Takahisa

机构信息

Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Department of Veterinary Public Health, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 12400, Vietnam.

出版信息

Antibiotics (Basel). 2023 Jun 20;12(6):1077. doi: 10.3390/antibiotics12061077.

DOI:10.3390/antibiotics12061077
PMID:37370397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10295611/
Abstract

Bacterial food poisoning cases due to and O157:H7 have been linked with the consumption of a variety of food products, threatening public health around the world. This study describes the combined effects of a phage cocktail (STG2, SEG5, and PS5), EDTA, nisin, and polylysine against the bacterial cocktail consisting of , , and O157:H7. Overall, phage cocktail (alone or in combination with nisin or/and polylysine) not only showed great antibacterial effects against bacterial cocktail at different temperatures (4 °C, 24 °C, and 37 °C), but also totally inhibited the emergence of phage resistance during the incubation period. These results suggest that the combination of phages with nisin or/and polylysine has great potential to simultaneously control , , and O157:H7.

摘要

由[未提及具体细菌名称]和O157:H7引起的细菌性食物中毒病例与多种食品的消费有关，威胁着世界各地的公众健康。本研究描述了一种噬菌体鸡尾酒（STG2、SEG5和PS5）、乙二胺四乙酸（EDTA）、乳酸链球菌素和聚赖氨酸对由[未提及具体细菌名称]、[未提及具体细菌名称]和O157:H7组成的细菌混合物的联合作用。总体而言，噬菌体鸡尾酒（单独或与乳酸链球菌素或/和聚赖氨酸联合使用）不仅在不同温度（4°C、24°C和37°C）下对细菌混合物显示出强大的抗菌作用，而且在培养期间完全抑制了噬菌体抗性的出现。这些结果表明，噬菌体与乳酸链球菌素或/和聚赖氨酸的组合具有同时控制[未提及具体细菌名称]、[未提及具体细菌名称]和O157:H7的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/1a91eed95a61/antibiotics-12-01077-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/c315fb9d32bc/antibiotics-12-01077-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/0402bcd148d5/antibiotics-12-01077-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/59d6a4ac89ec/antibiotics-12-01077-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/d9a05a6e5959/antibiotics-12-01077-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/1a91eed95a61/antibiotics-12-01077-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/c315fb9d32bc/antibiotics-12-01077-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/0402bcd148d5/antibiotics-12-01077-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/59d6a4ac89ec/antibiotics-12-01077-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/d9a05a6e5959/antibiotics-12-01077-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/10295611/1a91eed95a61/antibiotics-12-01077-g005.jpg

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