Reiter R C
Obstet Gynecol. 1986 Aug;68(2):237-40.
Five hundred twelve patients who presented with initial atypical cervical cytology between February 1982 and February 1983 at Naval Hospital, San Diego were randomized with respect to antibiotic treatment and interval before repeat cytologic examination. Treatment before repeat cytology did not improve the rate of reversion to normal cytology. Reexamination before three months, however, resulted in an increased rate of persistent atypical cytologies. Patients who failed to revert to normal cytology on repeat examination were found to be at substantial risk for development of cervical intraepithelial neoplasia (CIN). To date, adequate follow up and histologic diagnosis has been achieved for 110 such patients, 49 of whom (44.5%) have been found to harbor CIN. Patients in whom initial cytology demonstrated marked atypia unassociated with inflammation are particularly at risk (76.2%) for development of CIN.
1982年2月至1983年2月期间，圣地亚哥海军医院收治的512例初诊为非典型宫颈细胞学的患者，按照抗生素治疗及重复细胞学检查前的间隔时间进行了随机分组。重复细胞学检查前进行治疗并不能提高细胞学恢复正常的比例。然而，在三个月前进行复查会导致持续性非典型细胞学比例增加。复查时未能恢复正常细胞学的患者被发现患宫颈上皮内瘤变（CIN）的风险很大。迄今为止，对110例此类患者进行了充分的随访和组织学诊断，其中49例（44.5%）被发现患有CIN。最初细胞学显示有明显非典型性且与炎症无关的患者发生CIN的风险尤其高（76.2%）。
