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儿童睡眠呼吸暂停的诊断与治疗:需要一个未来视角。

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed.

作者信息

Solano-Pérez Esther, Coso Carlota, Castillo-García María, Romero-Peralta Sofía, Lopez-Monzoni Sonia, Laviña Eduardo, Cano-Pumarega Irene, Sánchez-de-la-Torre Manuel, García-Río Francisco, Mediano Olga

机构信息

Sleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, Spain.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain.

出版信息

Biomedicines. 2023 Jun 14;11(6):1708. doi: 10.3390/biomedicines11061708.

Abstract

Obstructive sleep apnea (OSA) in children is a prevalent, but still, today, underdiagnosed illness, which consists of repetitive episodes of upper airway obstruction during sleep with important repercussions for sleep quality. OSA has relevant consequences in the pediatric population, mainly in the metabolic, cardiovascular (CV), and neurological spheres. However, contrary to adults, advances in diagnostic and therapeutic management have been scarce in the last few years despite the increasing scientific evidence of the deleterious consequences of pediatric OSA. The problem of underdiagnosis and the lack of response to treatment in some groups make an update to the management of OSA in children necessary. Probably, the heterogeneity of OSA is not well represented by the classical clinical presentation and severity parameters (apnea/hypopnea index (AHI)), and new strategies are required. A specific and consensus definition should be established. Additionally, the role of simplified methods in the diagnosis algorithm should be considered. Finally, the search for new biomarkers for risk stratification is needed in this population. In conclusion, new paradigms based on personalized medicine should be implemented in this population.

摘要

儿童阻塞性睡眠呼吸暂停(OSA)是一种普遍存在但至今仍诊断不足的疾病,它由睡眠期间上气道反复阻塞发作组成,对睡眠质量有重要影响。OSA在儿科人群中有相关后果,主要在代谢、心血管(CV)和神经领域。然而,与成人不同的是,尽管越来越多的科学证据表明儿科OSA有有害后果,但在过去几年中,诊断和治疗管理方面的进展却很少。某些群体中诊断不足和治疗反应不佳的问题使得有必要更新儿童OSA的管理。可能,OSA的异质性没有通过经典的临床表现和严重程度参数(呼吸暂停/低通气指数(AHI))得到很好的体现,需要新的策略。应该建立一个具体的、达成共识的定义。此外,应考虑简化方法在诊断算法中的作用。最后,在这个人群中需要寻找用于风险分层的新生物标志物。总之,应该在这个人群中实施基于个性化医疗的新范式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/10296156/c406abe49ea6/biomedicines-11-01708-g001.jpg

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